Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 4844269..4845950 Replicon chromosome
Accession NZ_CP097190
Organism Klebsiella pneumoniae strain 15-652

Toxin (Protein)


Gene name mosT Uniprot ID A0A483YLF8
Locus tag M4I39_RS23555 Protein ID WP_019724882.1
Coordinates 4844269..4845186 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A6TH05
Locus tag M4I39_RS23560 Protein ID WP_004177809.1
Coordinates 4845192..4845950 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M4I39_RS23535 (4839575) 4839575..4841095 + 1521 WP_004210021.1 sugar ABC transporter ATP-binding protein -
M4I39_RS23540 (4841092) 4841092..4842090 + 999 WP_002885172.1 ribose ABC transporter permease -
M4I39_RS23545 (4842121) 4842121..4843062 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
M4I39_RS23550 (4843137) 4843137..4844144 + 1008 WP_064152101.1 carbohydrate kinase family protein -
M4I39_RS23555 (4844269) 4844269..4845186 - 918 WP_019724882.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
M4I39_RS23560 (4845192) 4845192..4845950 - 759 WP_004177809.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
M4I39_RS23565 (4846036) 4846036..4846764 - 729 WP_002885152.1 response regulator transcription factor -
M4I39_RS23570 (4847037) 4847037..4849184 + 2148 WP_077625403.1 formate dehydrogenase subunit alpha -
M4I39_RS23575 (4849414) 4849414..4850100 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(1-93)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34653.14 Da        Isoelectric Point: 5.4707

>T244894 WP_019724882.1 NZ_CP097190:c4845186-4844269 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CITQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28548.92 Da        Isoelectric Point: 10.0870

>AT244894 WP_004177809.1 NZ_CP097190:c4845950-4845192 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A483YLF8

Antitoxin

Source ID Structure
AlphaFold DB A6TH05

References