Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4687583..4688099 Replicon chromosome
Accession NZ_CP097190
Organism Klebsiella pneumoniae strain 15-652

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag M4I39_RS22745 Protein ID WP_004178374.1
Coordinates 4687583..4687867 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag M4I39_RS22750 Protein ID WP_002886901.1
Coordinates 4687857..4688099 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M4I39_RS22720 (4682978) 4682978..4683241 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
M4I39_RS22725 (4683371) 4683371..4683544 + 174 WP_032412860.1 hypothetical protein -
M4I39_RS22730 (4683547) 4683547..4684290 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
M4I39_RS22735 (4684647) 4684647..4686785 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
M4I39_RS22740 (4687115) 4687115..4687579 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
M4I39_RS22745 (4687583) 4687583..4687867 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M4I39_RS22750 (4687857) 4687857..4688099 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
M4I39_RS22755 (4688177) 4688177..4690087 - 1911 WP_004152270.1 PRD domain-containing protein -
M4I39_RS22760 (4690110) 4690110..4691264 - 1155 WP_002886900.1 lactonase family protein -
M4I39_RS22765 (4691331) 4691331..4692071 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T244893 WP_004178374.1 NZ_CP097190:c4687867-4687583 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT244893 WP_002886901.1 NZ_CP097190:c4688099-4687857 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References