Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2672611..2674199 Replicon chromosome
Accession NZ_CP097190
Organism Klebsiella pneumoniae strain 15-652

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag M4I39_RS13050 Protein ID WP_064151580.1
Coordinates 2672611..2673933 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag M4I39_RS13055 Protein ID WP_004176198.1
Coordinates 2673933..2674199 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M4I39_RS13035 (2667667) 2667667..2670168 + 2502 WP_064151582.1 fimbria/pilus outer membrane usher protein -
M4I39_RS13040 (2670156) 2670156..2671160 + 1005 WP_064151581.1 fimbrial protein -
M4I39_RS13045 (2671302) 2671302..2672594 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
M4I39_RS13050 (2672611) 2672611..2673933 - 1323 WP_064151580.1 type II toxin-antitoxin system HipA family toxin Toxin
M4I39_RS13055 (2673933) 2673933..2674199 - 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
M4I39_RS13060 (2674465) 2674465..2674791 - 327 WP_004176200.1 hydroxyisourate hydrolase -
M4I39_RS13065 (2674788) 2674788..2675288 - 501 WP_064151579.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
M4I39_RS13070 (2675266) 2675266..2676645 - 1380 WP_065799905.1 nucleobase:cation symporter-2 family protein -
M4I39_RS13075 (2676991) 2676991..2678145 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
M4I39_RS13080 (2678126) 2678126..2679049 - 924 WP_008804925.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49152.42 Da        Isoelectric Point: 7.2850

>T244890 WP_064151580.1 NZ_CP097190:c2673933-2672611 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
AHSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT244890 WP_004176198.1 NZ_CP097190:c2674199-2673933 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References