Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 799588..800245 Replicon chromosome
Accession NZ_CP097190
Organism Klebsiella pneumoniae strain 15-652

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag M4I39_RS03965 Protein ID WP_002916310.1
Coordinates 799835..800245 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag M4I39_RS03960 Protein ID WP_002916312.1
Coordinates 799588..799854 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M4I39_RS03935 (794744) 794744..796177 - 1434 WP_064152027.1 6-phospho-beta-glucosidase -
M4I39_RS03940 (796296) 796296..797024 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
M4I39_RS03945 (797074) 797074..797385 + 312 WP_064152028.1 N(4)-acetylcytidine aminohydrolase -
M4I39_RS03950 (797549) 797549..798208 + 660 WP_002916317.1 hemolysin III family protein -
M4I39_RS03955 (798359) 798359..799342 - 984 WP_064152029.1 tRNA-modifying protein YgfZ -
M4I39_RS03960 (799588) 799588..799854 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
M4I39_RS03965 (799835) 799835..800245 + 411 WP_002916310.1 protein YgfX Toxin
M4I39_RS03970 (800252) 800252..800773 - 522 WP_004144730.1 flavodoxin FldB -
M4I39_RS03975 (800874) 800874..801770 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
M4I39_RS03980 (801793) 801793..802506 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
M4I39_RS03985 (802512) 802512..804245 + 1734 WP_116984814.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T244885 WP_002916310.1 NZ_CP097190:799835-800245 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT244885 WP_002916312.1 NZ_CP097190:799588-799854 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References