Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 4805887..4806839 Replicon chromosome
Accession NZ_CP097186
Organism Rhodococcus sp. GA1

Toxin (Protein)


Gene name pezT Uniprot ID A0A0B1RG18
Locus tag M3330_RS22505 Protein ID WP_019289576.1
Coordinates 4806270..4806839 (+) Length 190 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID A0A385LF66
Locus tag M3330_RS22500 Protein ID WP_039585981.1
Coordinates 4805887..4806273 (+) Length 129 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3330_RS22475 4801493..4801825 - 333 WP_255026407.1 helix-turn-helix transcriptional regulator -
M3330_RS22480 4801822..4802928 - 1107 WP_031264746.1 tyrosine-type recombinase/integrase -
M3330_RS22485 4803658..4804158 + 501 WP_200358073.1 hypothetical protein -
M3330_RS22490 4804175..4804540 - 366 WP_024101068.1 HNH endonuclease -
M3330_RS22495 4804610..4805680 - 1071 WP_006552788.1 methyltransferase domain-containing protein -
M3330_RS22500 4805887..4806273 + 387 WP_039585981.1 hypothetical protein Antitoxin
M3330_RS22505 4806270..4806839 + 570 WP_019289576.1 zeta toxin family protein Toxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(4-136)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(7-79)


Sequences

Toxin        


Download         Length: 190 a.a.        Molecular weight: 20522.68 Da        Isoelectric Point: 10.6895

>T244883 WP_019289576.1 NZ_CP097186:4806270-4806839 [Rhodococcus sp. GA1]
MRRLDLIVGPNGSGKSTFVELSLAPLLPRSVFVNADVIARQRWPDRAEEMSYEAAQLAAAARDRLLRQGRSFIAETVFSH
PSKLELIDRAHEVGFTVVLHVMLVPEAMSVLRVQHRVASGGHAVPEDKIRARYRRLWPLVAEAIGRADQASVYDTASGTP
VVVARFAGGVPVGAVRWPGWAPAALTGLG

Download         Length: 570 bp

Antitoxin


Download         Length: 129 a.a.        Molecular weight: 14052.52 Da        Isoelectric Point: 4.7096

>AT244883 WP_039585981.1 NZ_CP097186:4805887-4806273 [Rhodococcus sp. GA1]
MTSSTDKVTRFDAELVDSAIAEGGRQNRTGRQQLEYWARIGRAMTAHETASLHRVHEALAGTRELSELTAAEGRLFDAEI
DARLADGLARTDYAEILAARGVTTVVLDDEGRLVEQRPDGSRRVLDDA

Download         Length: 387 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B1RG18

Antitoxin

Source ID Structure
AlphaFold DB A0A385LF66

References