Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3434634..3435252 Replicon chromosome
Accession NZ_CP097181
Organism Escherichia coli strain SH21PTE31

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag M4R35_RS16690 Protein ID WP_001291435.1
Coordinates 3435034..3435252 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag M4R35_RS16685 Protein ID WP_000344800.1
Coordinates 3434634..3435008 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M4R35_RS16675 (3429723) 3429723..3430916 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
M4R35_RS16680 (3430939) 3430939..3434088 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
M4R35_RS16685 (3434634) 3434634..3435008 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
M4R35_RS16690 (3435034) 3435034..3435252 + 219 WP_001291435.1 HHA domain-containing protein Toxin
M4R35_RS16695 (3435424) 3435424..3435975 + 552 WP_000102564.1 maltose O-acetyltransferase -
M4R35_RS16700 (3436091) 3436091..3436561 + 471 WP_000136192.1 YlaC family protein -
M4R35_RS16705 (3436725) 3436725..3438275 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
M4R35_RS16710 (3438317) 3438317..3438624 - 308 Protein_3284 DUF1428 family protein -
M4R35_RS16720 (3439003) 3439003..3439314 + 312 WP_000409911.1 MGMT family protein -
M4R35_RS16725 (3439345) 3439345..3439917 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T244874 WP_001291435.1 NZ_CP097181:3435034-3435252 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT244874 WP_000344800.1 NZ_CP097181:3434634-3435008 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References