Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 17468..18111 Replicon plasmid pAR13438_1
Accession NZ_CP097171
Organism Escherichia coli strain AR13438

Toxin (Protein)


Gene name vagD Uniprot ID B1LRW4
Locus tag M3M51_RS23895 Protein ID WP_001044768.1
Coordinates 17695..18111 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID D2WFK3
Locus tag M3M51_RS23890 Protein ID WP_001261287.1
Coordinates 17468..17698 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3M51_RS23870 (12628) 12628..13716 + 1089 WP_000952217.1 transcriptional repressor PifC -
M3M51_RS23875 (13718) 13718..15943 + 2226 WP_000698737.1 P-loop NTPase fold protein -
M3M51_RS23880 (15993) 15993..16892 - 900 WP_000963206.1 nucleotide-binding protein -
M3M51_RS23885 (16882) 16882..17172 - 291 WP_000111771.1 hypothetical protein -
M3M51_RS23890 (17468) 17468..17698 + 231 WP_001261287.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
M3M51_RS23895 (17695) 17695..18111 + 417 WP_001044768.1 type II toxin-antitoxin system VapC family toxin Toxin
M3M51_RS23900 (18273) 18273..20411 - 2139 WP_000350638.1 AAA family ATPase -
M3M51_RS23905 (20765) 20765..21022 + 258 WP_000343085.1 hypothetical protein -
M3M51_RS23910 (21022) 21022..21612 + 591 WP_000194574.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid dfrA12 / aadA2 / qacE / sul1 / rmtB / blaTEM-1B / sul2 / aph(3'')-Ib / aph(6)-Id / tet(A) / floR / blaCTX-M-27 / mph(A) / sitABCD - 1..124392 124392


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15197.66 Da        Isoelectric Point: 7.7805

>T244853 WP_001044768.1 NZ_CP097171:17695-18111 [Escherichia coli]
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDEFCARLDAILPWDRA
AVDATTKIKVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVPDLVLEDWVK

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8815.90 Da        Isoelectric Point: 4.3775

>AT244853 WP_001261287.1 NZ_CP097171:17468-17698 [Escherichia coli]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFLEYEKADPDFMAEREDVVSDEGRFNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A606Q844

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QFC4

References