Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4740334..4740950 Replicon chromosome
Accession NZ_CP097170
Organism Escherichia coli strain AR13438

Toxin (Protein)


Gene name vapC Uniprot ID A0A176ZIX8
Locus tag M3M51_RS22760 Protein ID WP_001129490.1
Coordinates 4740334..4740708 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1M0CY48
Locus tag M3M51_RS22765 Protein ID WP_001275523.1
Coordinates 4740708..4740950 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3M51_RS22745 (4737837) 4737837..4738739 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
M3M51_RS22750 (4738736) 4738736..4739371 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
M3M51_RS22755 (4739368) 4739368..4740297 + 930 WP_000027720.1 formate dehydrogenase accessory protein FdhE -
M3M51_RS22760 (4740334) 4740334..4740708 - 375 WP_001129490.1 type II toxin-antitoxin system VapC family toxin Toxin
M3M51_RS22765 (4740708) 4740708..4740950 - 243 WP_001275523.1 CopG family transcriptional regulator Antitoxin
M3M51_RS22770 (4741170) 4741170..4741388 - 219 WP_001251290.1 CopG family transcriptional regulator -
M3M51_RS22775 (4742062) 4742062..4742976 - 915 WP_072649161.1 transposase -
M3M51_RS22780 (4742989) 4742989..4743876 - 888 Protein_4457 hypothetical protein -
M3M51_RS22785 (4744292) 4744292..4745233 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
M3M51_RS22790 (4745278) 4745278..4745715 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-115)

Antitoxin

Ribbon-helix-helix protein, CopG

(15-48)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13960.19 Da        Isoelectric Point: 7.0126

>T244852 WP_001129490.1 NZ_CP097170:c4740708-4740334 [Escherichia coli]
MAKRTALFDTNILIDLFSGRIEAKQALEAWPLQNAISLVTWMEVLVGAKKYDQEHRTRIAMSAFNVIGISQDIAERSVAL
RQEYRMKLPDAIILATAQIYGFELVTRNTRDFAGIAGVVTPYEL

Download         Length: 375 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9290.54 Da        Isoelectric Point: 4.3774

>AT244852 WP_001275523.1 NZ_CP097170:c4740950-4740708 [Escherichia coli]
MSAMAGMDMGRILLDLSDEVIKRLDDLKVQRNLPRAELLREAVDQYLENQSKTTISSAFGIWQGCEEDGVEYQRKLREEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A176ZIX8

Antitoxin

Source ID Structure
AlphaFold DB A0A1M0CY48

References