Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4427394..4427891 Replicon chromosome
Accession NZ_CP097170
Organism Escherichia coli strain AR13438

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag M3M51_RS21350 Protein ID WP_001173343.1
Coordinates 4427394..4427567 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag M3M51_RS21355 Protein ID WP_000398619.1
Coordinates 4427595..4427891 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3M51_RS21340 (4424064) 4424064..4425521 + 1458 WP_061092757.1 dipeptide/tripeptide permease DtpC -
M3M51_RS21345 (4425758) 4425758..4427275 + 1518 WP_000003806.1 lysine--tRNA ligase -
M3M51_RS21350 (4427394) 4427394..4427567 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
M3M51_RS21355 (4427595) 4427595..4427891 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
M3M51_RS21360 (4428120) 4428120..4428392 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
M3M51_RS21365 (4428404) 4428404..4428634 - 231 WP_000371704.1 4Fe-4S mono-cluster protein YjdI -
M3M51_RS21370 (4428815) 4428815..4430446 + 1632 WP_061092758.1 sensor histidine kinase -
M3M51_RS21375 (4430443) 4430443..4431162 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T244851 WP_001173343.1 NZ_CP097170:c4427567-4427394 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT244851 WP_000398619.1 NZ_CP097170:c4427891-4427595 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References