Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4322795..4323390 Replicon chromosome
Accession NZ_CP097170
Organism Escherichia coli strain AR13438

Toxin (Protein)


Gene name chpB Uniprot ID V0SXT4
Locus tag M3M51_RS20815 Protein ID WP_000239581.1
Coordinates 4322795..4323145 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID L4JJX7
Locus tag M3M51_RS20820 Protein ID WP_001223213.1
Coordinates 4323139..4323390 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3M51_RS20795 (4318249) 4318249..4319271 - 1023 WP_001361374.1 ABC transporter permease -
M3M51_RS20800 (4319285) 4319285..4320787 - 1503 WP_001095661.1 ATP-binding cassette domain-containing protein -
M3M51_RS20805 (4320920) 4320920..4321876 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
M3M51_RS20810 (4322186) 4322186..4322716 + 531 WP_000055072.1 inorganic diphosphatase -
M3M51_RS20815 (4322795) 4322795..4323145 - 351 WP_000239581.1 endoribonuclease toxin ChpB Toxin
M3M51_RS20820 (4323139) 4323139..4323390 - 252 WP_001223213.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
M3M51_RS20825 (4323602) 4323602..4323943 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
M3M51_RS20830 (4323946) 4323946..4327725 - 3780 WP_000060873.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12453.41 Da        Isoelectric Point: 6.2206

>T244850 WP_000239581.1 NZ_CP097170:c4323145-4322795 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9331.64 Da        Isoelectric Point: 4.6509

>AT244850 WP_001223213.1 NZ_CP097170:c4323390-4323139 [Escherichia coli]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SXT4

Antitoxin

Source ID Structure
AlphaFold DB L4JJX7

References