244849

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4311451..4311973 Replicon chromosome
Accession NZ_CP097170
Organism Escherichia coli strain AR13438

Toxin (Protein)


Gene name relE Uniprot ID V0SDB6
Locus tag M3M51_RS20755 Protein ID WP_001105432.1
Coordinates 4311451..4311741 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V0SC69
Locus tag M3M51_RS20760 Protein ID WP_000212715.1
Coordinates 4311731..4311973 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3M51_RS20740 (4306614) 4306614..4308269 + 1656 WP_001361372.1 alpha,alpha-phosphotrehalase -
M3M51_RS20745 (4308663) 4308663..4310801 + 2139 WP_000187798.1 anaerobic ribonucleoside-triphosphate reductase -
M3M51_RS20750 (4310986) 4310986..4311450 + 465 WP_001009180.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
M3M51_RS20755 (4311451) 4311451..4311741 - 291 WP_001105432.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M3M51_RS20760 (4311731) 4311731..4311973 - 243 WP_000212715.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
M3M51_RS20765 (4312165) 4312165..4312551 - 387 WP_001232253.1 cytochrome b562 -
M3M51_RS20770 (4312607) 4312607..4313959 - 1353 WP_001162172.1 metalloprotease PmbA -
M3M51_RS20775 (4314053) 4314053..4314604 + 552 WP_000166270.1 ribosome biogenesis factor YjgA -
M3M51_RS20780 (4314687) 4314687..4316060 - 1374 WP_001219814.1 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-72)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11311.21 Da        Isoelectric Point: 10.0238

>T244849 WP_001105432.1 NZ_CP097170:c4311741-4311451 [Escherichia coli]
MNYELAFDPRALKEWQKLGVTVREQFKKKLEDVLKRPRNPSAKLRDLPDCYKIKLRTLGYRLVYSVNDKELLVLVIAIGK
RENSAVYEDATKRLDE

Download         Length: 291 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9125.56 Da        Isoelectric Point: 5.1369

>AT244849 WP_000212715.1 NZ_CP097170:c4311973-4311731 [Escherichia coli]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAENGRMPVKTLTVSDSEEALLRTVRERLANPQEAIKVRLDEL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SDB6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9H4B3

References