244847

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) itaRT/DUF1778(antitoxin)
Location 3791880..3792717 Replicon chromosome
Accession NZ_CP097170
Organism Escherichia coli strain AR13438

Toxin (Protein)


Gene name itaT Uniprot ID A0A1M0D5U3
Locus tag M3M51_RS18255 Protein ID WP_000227782.1
Coordinates 3792175..3792717 (+) Length 181 a.a.

Antitoxin (Protein)


Gene name itaR Uniprot ID B1LJI1
Locus tag M3M51_RS18250 Protein ID WP_001353405.1
Coordinates 3791880..3792191 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3M51_RS18225 (3786900) 3786900..3787847 + 948 WP_001239437.1 cytochrome o ubiquinol oxidase subunit II -
M3M51_RS18230 (3787869) 3787869..3789860 + 1992 WP_000467180.1 cytochrome o ubiquinol oxidase subunit I -
M3M51_RS18235 (3789850) 3789850..3790464 + 615 WP_000179819.1 cytochrome o ubiquinol oxidase subunit III -
M3M51_RS18240 (3790464) 3790464..3790793 + 330 WP_000019869.1 cytochrome o ubiquinol oxidase subunit IV -
M3M51_RS18245 (3790805) 3790805..3791695 + 891 WP_000971327.1 heme o synthase -
M3M51_RS18250 (3791880) 3791880..3792191 + 312 WP_001353405.1 DUF1778 domain-containing protein Antitoxin
M3M51_RS18255 (3792175) 3792175..3792717 + 543 WP_000227782.1 GNAT family N-acetyltransferase Toxin
M3M51_RS18260 (3792773) 3792773..3793617 - 845 Protein_3581 tetratricopeptide repeat protein -
M3M51_RS18265 (3794024) 3794024..3795388 + 1365 WP_001000978.1 MFS transporter -
M3M51_RS18270 (3795516) 3795516..3796007 - 492 WP_001138904.1 nucleotide binding protein YajQ -
M3M51_RS18275 (3796175) 3796175..3797086 + 912 WP_000705841.1 2-dehydropantoate 2-reductase -
M3M51_RS18280 (3797049) 3797049..3797639 + 591 WP_001276320.1 protein deglycase YajL -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(68-156)

Antitoxin

Vibrio phage ICP1, Orf50

(19-96)


Sequences

Toxin        


Download         Length: 181 a.a.        Molecular weight: 19957.31 Da        Isoelectric Point: 9.1763

>T244847 WP_000227782.1 NZ_CP097170:3792175-3792717 [Escherichia coli]
MVDKHEEITLPIVLSCNYQSDIIYPGQKQFDCGNPVIDKFVRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLEK
QRVSGVLQGSQPSEIGVVRLVMLGVARKYQKRGFGQDLLCNFFEHVKIIHRALPIKGVYLDADPAAINFYTRLGFVQLSA
RPNVFGAVPMFLAIQHILAA

Download         Length: 543 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11370.09 Da        Isoelectric Point: 10.4825

>AT244847 WP_001353405.1 NZ_CP097170:3791880-3792191 [Escherichia coli]
MPGKTVALPDIDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1M0D5U3

Antitoxin

Source ID Structure
AlphaFold DB A0A829G7G3

References