Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3757790..3758408 Replicon chromosome
Accession NZ_CP097170
Organism Escherichia coli strain AR13438

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag M3M51_RS18085 Protein ID WP_001291435.1
Coordinates 3758190..3758408 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag M3M51_RS18080 Protein ID WP_000344800.1
Coordinates 3757790..3758164 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3M51_RS18070 (3752879) 3752879..3754072 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
M3M51_RS18075 (3754095) 3754095..3757244 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
M3M51_RS18080 (3757790) 3757790..3758164 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
M3M51_RS18085 (3758190) 3758190..3758408 + 219 WP_001291435.1 HHA domain-containing protein Toxin
M3M51_RS18090 (3758580) 3758580..3759131 + 552 WP_000102574.1 maltose O-acetyltransferase -
M3M51_RS18095 (3759247) 3759247..3759717 + 471 WP_000136192.1 YlaC family protein -
M3M51_RS18100 (3759881) 3759881..3761431 + 1551 WP_001361689.1 cyclic-guanylate-specific phosphodiesterase PdeB -
M3M51_RS18105 (3761473) 3761473..3761826 - 354 WP_000878140.1 DUF1428 domain-containing protein -
M3M51_RS18115 (3762205) 3762205..3762516 + 312 WP_000409911.1 MGMT family protein -
M3M51_RS18120 (3762547) 3762547..3763119 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T244846 WP_001291435.1 NZ_CP097170:3758190-3758408 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT244846 WP_000344800.1 NZ_CP097170:3757790-3758164 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References