Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 3328697..3329402 Replicon chromosome
Accession NZ_CP097170
Organism Escherichia coli strain AR13438

Toxin (Protein)


Gene name relE Uniprot ID A0A1M2J6W7
Locus tag M3M51_RS15915 Protein ID WP_000539524.1
Coordinates 3328697..3329083 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag M3M51_RS15920 Protein ID WP_001280945.1
Coordinates 3329073..3329402 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3M51_RS15895 (3324701) 3324701..3325327 + 627 WP_001295292.1 glutathione S-transferase GstB -
M3M51_RS15900 (3325324) 3325324..3326439 - 1116 WP_000555056.1 aldose sugar dehydrogenase YliI -
M3M51_RS15905 (3326550) 3326550..3326933 - 384 WP_000497137.1 biofilm formation regulator BssR -
M3M51_RS15910 (3327146) 3327146..3328471 + 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
M3M51_RS15915 (3328697) 3328697..3329083 + 387 WP_000539524.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M3M51_RS15920 (3329073) 3329073..3329402 + 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
M3M51_RS15925 (3329472) 3329472..3330789 - 1318 Protein_3130 diguanylate cyclase -
M3M51_RS15930 (3330797) 3330797..3333145 - 2349 WP_000950331.1 EAL domain-containing protein -
M3M51_RS15935 (3333322) 3333322..3334233 - 912 WP_001236044.1 glutathione ABC transporter permease GsiD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14321.46 Da        Isoelectric Point: 9.9521

>T244844 WP_000539524.1 NZ_CP097170:3328697-3329083 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSRSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT244844 WP_001280945.1 NZ_CP097170:3329073-3329402 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1M2J6W7

Antitoxin

Source ID Structure

References