Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 363557..364188 Replicon chromosome
Accession NZ_CP097170
Organism Escherichia coli strain AR13438

Toxin (Protein)


Gene name hicA Uniprot ID L4J012
Locus tag M3M51_RS01625 Protein ID WP_001260301.1
Coordinates 363557..363832 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag M3M51_RS01630 Protein ID WP_000593555.1
Coordinates 363829..364188 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3M51_RS01610 (358561) 358561..359628 + 1068 WP_000361497.1 HlyD family efflux transporter periplasmic adaptor subunit -
M3M51_RS01615 (359625) 359625..362360 + 2736 WP_061092822.1 ribosome-associated ATPase/putative transporter RbbA -
M3M51_RS01620 (362360) 362360..363484 + 1125 WP_001314210.1 ABC transporter permease -
M3M51_RS01625 (363557) 363557..363832 + 276 WP_001260301.1 type II toxin-antitoxin system HicA family toxin Toxin
M3M51_RS01630 (363829) 363829..364188 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
M3M51_RS01635 (364308) 364308..364709 - 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
M3M51_RS01640 (364714) 364714..365520 - 807 WP_061092823.1 nickel import ATP-binding protein NikE -
M3M51_RS01645 (365517) 365517..366281 - 765 WP_001136211.1 nickel import ATP-binding protein NikD -
M3M51_RS01650 (366281) 366281..367114 - 834 WP_001008963.1 nickel ABC transporter permease subunit NikC -
M3M51_RS01655 (367111) 367111..368055 - 945 WP_000947080.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 356573..364709 8136


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10185.87 Da        Isoelectric Point: 10.6128

>T244831 WP_001260301.1 NZ_CP097170:363557-363832 [Escherichia coli]
MRTQVQALRKKQKNTLDQIFKSPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT244831 WP_000593555.1 NZ_CP097170:363829-364188 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB L4J012

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References