Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 223429..224041 Replicon chromosome
Accession NZ_CP097170
Organism Escherichia coli strain AR13438

Toxin (Protein)


Gene name hicA Uniprot ID U9YXE2
Locus tag M3M51_RS01015 Protein ID WP_000833473.1
Coordinates 223429..223614 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A1M2IVK0
Locus tag M3M51_RS01020 Protein ID WP_000499742.1
Coordinates 223631..224041 (+) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3M51_RS01000 (218895) 218895..220190 + 1296 WP_000985745.1 Fic family protein -
M3M51_RS01005 (220298) 220298..221836 + 1539 WP_000183978.1 aldehyde dehydrogenase AldB -
M3M51_RS01010 (221877) 221877..222956 - 1080 WP_000061475.1 type I restriction enzyme HsdR N-terminal domain-containing protein -
M3M51_RS01015 (223429) 223429..223614 + 186 WP_000833473.1 type II toxin-antitoxin system HicA family toxin Toxin
M3M51_RS01020 (223631) 223631..224041 + 411 WP_000499742.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
M3M51_RS01025 (224153) 224153..226132 - 1980 WP_001026863.1 glycoside hydrolase family 127 protein -
M3M51_RS01030 (226143) 226143..227543 - 1401 WP_000204814.1 MFS transporter -
M3M51_RS01035 (227769) 227769..228584 + 816 WP_000891820.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6800.89 Da        Isoelectric Point: 11.7053

>T244830 WP_000833473.1 NZ_CP097170:223429-223614 [Escherichia coli]
VKSADVIAILKQHGWEHIRTRGSHHQFRHPVHPGLVTVPHPKKDIKPGTLAQIGRQAGLTF

Download         Length: 186 bp

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 15242.13 Da        Isoelectric Point: 4.4482

>AT244830 WP_000499742.1 NZ_CP097170:223631-224041 [Escherichia coli]
MFYPAYIHSDPDGSASGFFPDVPGCYFAGDTLDNAFQDARSALVAHFETLCEMDEELPLPGSVETHLVQRAQDFIGGQWL
LVDINMNQFEGRAERINITMPKRLLNKIDTYVRNNPDYANRSAFLAEAARRVLPGV

Download         Length: 411 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YXE2

Antitoxin

Source ID Structure
AlphaFold DB A0A1M2IVK0

References