Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 8170..8810 Replicon plasmid unnamed9
Accession NZ_CP097155
Organism Deinococcus sp. QL22

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag M1R55_RS27830 Protein ID WP_249396460.1
Coordinates 8403..8810 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag M1R55_RS27825 Protein ID WP_249396459.1
Coordinates 8170..8406 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1R55_RS27815 (M1R55_27810) 4930..6045 - 1116 WP_249396457.1 diguanylate cyclase -
M1R55_RS27820 (M1R55_27815) 6730..8088 + 1359 WP_249396458.1 hypothetical protein -
M1R55_RS27825 (M1R55_27820) 8170..8406 + 237 WP_249396459.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
M1R55_RS27830 (M1R55_27825) 8403..8810 + 408 WP_249396460.1 type II toxin-antitoxin system VapC family toxin Toxin
M1R55_RS27835 (M1R55_27830) 8921..9202 + 282 WP_249396461.1 HNH endonuclease -
M1R55_RS27840 (M1R55_27835) 9223..9933 - 711 WP_249396462.1 IS6 family transposase -
M1R55_RS31920 9920..10054 + 135 WP_256566078.1 hypothetical protein -
M1R55_RS27845 (M1R55_27840) 10095..10415 - 321 WP_249396463.1 hypothetical protein -
M1R55_RS27850 (M1R55_27845) 10526..11548 - 1023 WP_249396464.1 site-specific integrase -
M1R55_RS27855 (M1R55_27850) 11670..13055 - 1386 WP_249396465.1 toll/interleukin-1 receptor domain-containing protein -
M1R55_RS27860 (M1R55_27855) 13182..13525 + 344 Protein_16 IS982 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..201406 201406
- flank IS/Tn - - 9223..9897 674


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-126)

Antitoxin

SpoVT-AbrB domain

(7-45)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14860.14 Da        Isoelectric Point: 6.7195

>T244827 WP_249396460.1 NZ_CP097155:8403-8810 [Deinococcus sp. QL22]
MTLRYLLDTNICIFIIKNKPAAVRERFTGLRPGEVGLSAVTEAELLHGVYKSIRVEHNLAAVLDFASQLVIVPFDSQVAD
TYGRIRAELEKAGQPIGPLDFQIAATAVAHGLTLVTNNTREFARAPGLRMEDWTP

Download         Length: 408 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8737.81 Da        Isoelectric Point: 4.6128

>AT244827 WP_249396459.1 NZ_CP097155:8170-8406 [Deinococcus sp. QL22]
MTTAKVFQSGNSQAVRLPRELRLDVSEVEITRHGDLLILRPIRREATLASAFDALAGIGDDFLPEERQQGEAQEREAF

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References