Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-CcdA
Location 2659140..2659740 Replicon chromosome
Accession NZ_CP097128
Organism Conexibacter sp. DBS9H8

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag M3M55_RS12645 Protein ID WP_249009863.1
Coordinates 2659354..2659740 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag M3M55_RS12640 Protein ID WP_249009862.1
Coordinates 2659140..2659361 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3M55_RS12615 2655741..2657009 - 1269 WP_249009858.1 histidine--tRNA ligase -
M3M55_RS12620 2657046..2657696 - 651 WP_249009859.1 MBL fold metallo-hydrolase -
M3M55_RS12625 2657693..2658073 - 381 WP_249009860.1 hypothetical protein -
M3M55_RS12630 2658079..2658918 - 840 WP_249009861.1 hypothetical protein -
M3M55_RS12640 2659140..2659361 + 222 WP_249009862.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
M3M55_RS12645 2659354..2659740 + 387 WP_249009863.1 PIN domain-containing protein Toxin
M3M55_RS12650 2659824..2660882 - 1059 WP_249009864.1 sigma factor-like helix-turn-helix DNA-binding protein -
M3M55_RS12655 2660875..2661660 - 786 WP_249009865.1 hypothetical protein -
M3M55_RS12660 2661896..2663533 + 1638 WP_249009866.1 ATP-binding cassette domain-containing protein -
M3M55_RS12665 2663542..2664588 - 1047 WP_249009867.1 quinolinate synthase NadA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-120)

Antitoxin

Post-segregation antitoxin CcdA

(3-46)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 13458.56 Da        Isoelectric Point: 6.4791

>T244819 WP_249009863.1 NZ_CP097128:2659354-2659740 [Conexibacter sp. DBS9H8]
VPESVVLDSSAMVEALMGTQLGRATRARLRGCELHAPAHFDAEVLSAVGRLHRAGELDATIVSTSLNELAVAPIVRHPLA
GLLIGAWAARDRLRLVDALYVELSTVLGAVLVTTDARLARSTAADLVS

Download         Length: 387 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8048.02 Da        Isoelectric Point: 4.5720

>AT244819 WP_249009862.1 NZ_CP097128:2659140-2659361 [Conexibacter sp. DBS9H8]
MARVNVYLPDELAERARAAGVNISGVTQDALRGALASVDTDRWLDRLERLPARDVAHERVICALDEAREDFGA

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References