Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4565329..4565945 Replicon chromosome
Accession NZ_CP097107
Organism Citrobacter freundii strain GMU8049

Toxin (Protein)


Gene name vapC Uniprot ID A0A0J1MQ96
Locus tag M3L74_RS22705 Protein ID WP_003028682.1
Coordinates 4565329..4565703 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag M3L74_RS22710 Protein ID WP_161800368.1
Coordinates 4565703..4565945 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3L74_RS22690 (4562832) 4562832..4563734 + 903 WP_016155183.1 formate dehydrogenase O subunit beta -
M3L74_RS22695 (4563731) 4563731..4564366 + 636 WP_003028686.1 formate dehydrogenase cytochrome b556 subunit -
M3L74_RS22700 (4564363) 4564363..4565292 + 930 WP_003840450.1 formate dehydrogenase accessory protein FdhE -
M3L74_RS22705 (4565329) 4565329..4565703 - 375 WP_003028682.1 type II toxin-antitoxin system VapC family toxin Toxin
M3L74_RS22710 (4565703) 4565703..4565945 - 243 WP_161800368.1 CopG family transcriptional regulator Antitoxin
M3L74_RS22715 (4566151) 4566151..4567059 + 909 WP_088902891.1 alpha/beta hydrolase -
M3L74_RS22720 (4567210) 4567210..4568151 - 942 WP_003825286.1 fatty acid biosynthesis protein FabY -
M3L74_RS22725 (4568196) 4568196..4568633 - 438 WP_044714708.1 D-aminoacyl-tRNA deacylase -
M3L74_RS22730 (4568630) 4568630..4569502 - 873 WP_003028669.1 virulence factor BrkB family protein -
M3L74_RS22735 (4569496) 4569496..4570095 - 600 WP_016151258.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Ribbon-helix-helix protein, CopG

(13-47)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13674.89 Da        Isoelectric Point: 9.5622

>T244796 WP_003028682.1 NZ_CP097107:c4565703-4565329 [Citrobacter freundii]
MVKGSALFDTNILIDLFSGRNEAKLAIETWPPQNAISLITWMEVMVGAKKYHQEARTRVALGAFNVIGVSQDIAERSVSI
RQEYGMKLPDAIILATAQIHRLTLVTRNTKDFAGLSGVVTPYTL

Download         Length: 375 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9450.81 Da        Isoelectric Point: 4.5498

>AT244796 WP_161800368.1 NZ_CP097107:c4565945-4565703 [Citrobacter freundii]
MMAGMDMGRILLDLSDEVIKRLDDLKVQRNLPRAELLREAVEQYLERQDQAKTTISRALGLWQGCEEDGVEYQRKLREEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1MQ96

Antitoxin

Source ID Structure

References