Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4264827..4265630 Replicon chromosome
Accession NZ_CP097107
Organism Citrobacter freundii strain GMU8049

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag M3L74_RS21350 Protein ID WP_088902821.1
Coordinates 4265250..4265630 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A7L6TXP6
Locus tag M3L74_RS21345 Protein ID WP_047358708.1
Coordinates 4264827..4265192 (+) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3L74_RS21305 (4259900) 4259900..4260787 + 888 WP_047358715.1 50S ribosome-binding GTPase -
M3L74_RS21310 (4260993) 4260993..4261394 + 402 WP_088902817.1 hypothetical protein -
M3L74_RS21315 (4261491) 4261491..4261958 + 468 WP_047358713.1 hypothetical protein -
M3L74_RS21320 (4262149) 4262149..4262400 + 252 WP_047358712.1 DUF905 family protein -
M3L74_RS21325 (4262518) 4262518..4263336 + 819 WP_088902818.1 DUF932 domain-containing protein -
M3L74_RS21330 (4263605) 4263605..4264078 + 474 WP_047358733.1 antirestriction protein -
M3L74_RS21335 (4264091) 4264091..4264570 + 480 WP_047358710.1 DNA repair protein RadC -
M3L74_RS21340 (4264584) 4264584..4264805 + 222 WP_047358709.1 DUF987 domain-containing protein -
M3L74_RS21345 (4264827) 4264827..4265192 + 366 WP_047358708.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
M3L74_RS21350 (4265250) 4265250..4265630 + 381 WP_088902821.1 TA system toxin CbtA family protein Toxin
M3L74_RS21355 (4265627) 4265627..4266118 + 492 WP_047358706.1 DUF5983 family protein -
M3L74_RS21360 (4266192) 4266192..4266359 + 168 WP_072058785.1 DUF957 domain-containing protein -
M3L74_RS21365 (4266440) 4266440..4267288 + 849 WP_047358705.1 DUF4942 domain-containing protein -
M3L74_RS21370 (4268083) 4268083..4269744 + 1662 WP_088902822.1 fatty acid--CoA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-110)

Antitoxin

Antitoxin CbeA

(15-114)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14182.37 Da        Isoelectric Point: 10.0929

>T244795 WP_088902821.1 NZ_CP097107:4265250-4265630 [Citrobacter freundii]
MQTLSAIPTRKAPSHPTPVEIWQQLLTYLLKRHYGLSLSDTQFSDEKIITQYIDAGISLSDALNFLVEKSELVRIDRPGL
SIKHQSPFIGVIDILRARRATGLMQRNGYKRITLLIAGNAAQEQHS

Download         Length: 381 bp

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13417.25 Da        Isoelectric Point: 6.4780

>AT244795 WP_047358708.1 NZ_CP097107:4264827-4265192 [Citrobacter freundii]
MSNQLPPVNHDVSEPWWGLKPGITPCFGARLVQEGNRLHYLADRASIAGVFSDADLRHLDQAFPALLKQLELMLVSGELN
PRHQHCVTLYAKGLTCEADSLGSHGYIYTAMYPTPDNSITR

Download         Length: 366 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7L6TXP6

References