Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4126290..4126806 Replicon chromosome
Accession NZ_CP097107
Organism Citrobacter freundii strain GMU8049

Toxin (Protein)


Gene name relE Uniprot ID A0A0D7LMW6
Locus tag M3L74_RS20605 Protein ID WP_003839578.1
Coordinates 4126290..4126574 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0J1MV10
Locus tag M3L74_RS20610 Protein ID WP_003839576.1
Coordinates 4126564..4126806 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3L74_RS20590 (4121516) 4121516..4123168 + 1653 WP_088902791.1 alpha,alpha-phosphotrehalase -
M3L74_RS20595 (4123577) 4123577..4125715 + 2139 WP_003844922.1 anaerobic ribonucleoside-triphosphate reductase -
M3L74_RS20600 (4125822) 4125822..4126286 + 465 WP_088902792.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
M3L74_RS20605 (4126290) 4126290..4126574 - 285 WP_003839578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M3L74_RS20610 (4126564) 4126564..4126806 - 243 WP_003839576.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
M3L74_RS20615 (4126884) 4126884..4128797 - 1914 WP_061548941.1 BglG family transcription antiterminator -
M3L74_RS20620 (4128819) 4128819..4129559 - 741 WP_003025772.1 KDGP aldolase family protein -
M3L74_RS20625 (4129556) 4129556..4130674 - 1119 WP_003025770.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
M3L74_RS20630 (4130658) 4130658..4131791 - 1134 WP_049002371.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-69)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10866.68 Da        Isoelectric Point: 10.0482

>T244794 WP_003839578.1 NZ_CP097107:c4126574-4126290 [Citrobacter freundii]
MTYELEFDPRALKEWHKLGDTVKAQFKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDEVVTVFVVAVGK
REHSAVYLDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT244794 WP_003839576.1 NZ_CP097107:c4126806-4126564 [Citrobacter freundii]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTVSDSEDTLIQTVRERLASPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D7LMW6

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1MV10

References