Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3463220..3463840 Replicon chromosome
Accession NZ_CP097107
Organism Citrobacter freundii strain GMU8049

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag M3L74_RS17505 Protein ID WP_002892050.1
Coordinates 3463622..3463840 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID R8WZW8
Locus tag M3L74_RS17500 Protein ID WP_003021733.1
Coordinates 3463220..3463594 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3L74_RS17490 (3458366) 3458366..3459559 + 1194 WP_088902653.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
M3L74_RS17495 (3459582) 3459582..3462731 + 3150 WP_003021736.1 efflux RND transporter permease AcrB -
M3L74_RS17500 (3463220) 3463220..3463594 + 375 WP_003021733.1 Hha toxicity modulator TomB Antitoxin
M3L74_RS17505 (3463622) 3463622..3463840 + 219 WP_002892050.1 HHA domain-containing protein Toxin
M3L74_RS17510 (3464022) 3464022..3464573 + 552 WP_044712836.1 maltose O-acetyltransferase -
M3L74_RS17515 (3464690) 3464690..3465160 + 471 WP_003021724.1 YlaC family protein -
M3L74_RS17520 (3465238) 3465238..3465378 - 141 WP_005125190.1 type B 50S ribosomal protein L36 -
M3L74_RS17525 (3465380) 3465380..3465640 - 261 WP_003021719.1 type B 50S ribosomal protein L31 -
M3L74_RS17530 (3465829) 3465829..3467382 + 1554 WP_044712838.1 EAL domain-containing protein -
M3L74_RS17535 (3467434) 3467434..3467787 - 354 WP_003831033.1 DUF1428 family protein -
M3L74_RS17540 (3467852) 3467852..3468481 - 630 WP_003835929.1 membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T244791 WP_002892050.1 NZ_CP097107:3463622-3463840 [Citrobacter freundii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14427.23 Da        Isoelectric Point: 5.5653

>AT244791 WP_003021733.1 NZ_CP097107:3463220-3463594 [Citrobacter freundii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB R8WZW8

References