Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 645986..646640 Replicon chromosome
Accession NZ_CP097107
Organism Citrobacter freundii strain GMU8049

Toxin (Protein)


Gene name cptA Uniprot ID A0A0J1NHY7
Locus tag M3L74_RS03630 Protein ID WP_003026936.1
Coordinates 646233..646640 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A6H3AT26
Locus tag M3L74_RS03625 Protein ID WP_003026938.1
Coordinates 645986..646252 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3L74_RS03600 (641187) 641187..642620 - 1434 WP_088903082.1 6-phospho-beta-glucosidase BglA -
M3L74_RS03605 (642741) 642741..643469 - 729 WP_060855085.1 MurR/RpiR family transcriptional regulator -
M3L74_RS03610 (643522) 643522..643833 + 312 WP_044700802.1 N(4)-acetylcytidine aminohydrolase -
M3L74_RS03615 (643996) 643996..644655 + 660 WP_003838267.1 hemolysin III family protein -
M3L74_RS03620 (644749) 644749..645729 - 981 WP_088903083.1 tRNA-modifying protein YgfZ -
M3L74_RS03625 (645986) 645986..646252 + 267 WP_003026938.1 FAD assembly factor SdhE Antitoxin
M3L74_RS03630 (646233) 646233..646640 + 408 WP_003026936.1 protein YgfX Toxin
M3L74_RS03635 (646685) 646685..647206 - 522 WP_003026933.1 flavodoxin FldB -
M3L74_RS03640 (647320) 647320..648216 + 897 WP_249018363.1 site-specific tyrosine recombinase XerD -
M3L74_RS03645 (648240) 648240..648953 + 714 WP_003825520.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
M3L74_RS03650 (648959) 648959..650692 + 1734 WP_048232743.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15953.89 Da        Isoelectric Point: 11.4054

>T244785 WP_003026936.1 NZ_CP097107:646233-646640 [Citrobacter freundii]
VVQWQSDLRVSWRAQWLSLLIHGLVAVFILLMPWPLSYTPLWLVLLSLVVFDSVRSQRRINACQGEIRLLMDGRLRWQGQ
EWSIVSAPWMVKTGMMLRLRSDAGKRQHLWLAADSMDDAEWRDLRRLMLQKAKQK

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10558.09 Da        Isoelectric Point: 5.1700

>AT244785 WP_003026938.1 NZ_CP097107:645986-646252 [Citrobacter freundii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFIRLLECDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1NHY7

Antitoxin

Source ID Structure
AlphaFold DB A0A6H3AT26

References