Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 6850..7481 Replicon chromosome
Accession NZ_CP097107
Organism Citrobacter freundii strain GMU8049

Toxin (Protein)


Gene name hicA Uniprot ID A0A0J1MPQ6
Locus tag M3L74_RS00345 Protein ID WP_003837806.1
Coordinates 6850..7125 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0J1MMS0
Locus tag M3L74_RS00350 Protein ID WP_003837808.1
Coordinates 7122..7481 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3L74_RS00335 (2901) 2901..5648 + 2748 WP_003846160.1 ribosome-associated ATPase/putative transporter RbbA -
M3L74_RS00340 (5648) 5648..6772 + 1125 WP_003837801.1 ABC transporter permease -
M3L74_RS00345 (6850) 6850..7125 + 276 WP_003837806.1 type II toxin-antitoxin system HicA family toxin Toxin
M3L74_RS00350 (7122) 7122..7481 + 360 WP_003837808.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
M3L74_RS00355 (7594) 7594..7995 - 402 WP_003023387.1 nickel-responsive transcriptional regulator NikR -
M3L74_RS00360 (8045) 8045..8623 - 579 WP_003023390.1 4'-phosphopantetheinyl transferase AcpT -
M3L74_RS00365 (8686) 8686..9735 - 1050 WP_003023393.1 AI-2E family transporter -
M3L74_RS00370 (9869) 9869..11086 + 1218 WP_103798319.1 MFS transporter -
M3L74_RS00375 (11090) 11090..11647 - 558 WP_003837816.1 DcrB family lipoprotein -
M3L74_RS00380 (11720) 11720..12385 - 666 WP_003837818.1 7-cyano-7-deazaguanine/7-aminomethyl-7- deazaguanine transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10210.88 Da        Isoelectric Point: 10.7228

>T244782 WP_003837806.1 NZ_CP097107:6850-7125 [Citrobacter freundii]
MKEKVLSLRKKQKNTLDQLFKAPTPQGIKWSEIESLIKALGGEIKEGRGSRCKFLLNKSIASFHRPHPSPDTDKGAVENV
RDWLTSIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13198.98 Da        Isoelectric Point: 4.5462

>AT244782 WP_003837808.1 NZ_CP097107:7122-7481 [Citrobacter freundii]
MIKPKTPNSMEIAGQPAVINYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGEISLREYLDDCSAAGIEPYANPEKLKT
FTLRYPESFGERLSFAAAEEQVSVNTWIIETLSKSLKQA

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1MPQ6

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1MMS0

References