Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpB-mazE/PRK09812-ChpS
Location 45044..45642 Replicon plasmid pNY11382-NR
Accession NZ_CP097105
Organism Pseudomonas sp. NY11382

Toxin (Protein)


Gene name chpB Uniprot ID A0A2V4KLX1
Locus tag M2J80_RS28595 Protein ID WP_023118080.1
Coordinates 45044..45397 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A6H1Q8V4
Locus tag M2J80_RS28600 Protein ID WP_009684309.1
Coordinates 45394..45642 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2J80_RS28565 (M2J80_28555) 40605..40922 + 318 WP_110389097.1 hypothetical protein -
M2J80_RS28570 (M2J80_28560) 41160..41576 + 417 WP_033690668.1 hypothetical protein -
M2J80_RS28575 (M2J80_28565) 41763..43109 + 1347 WP_009684314.1 replicative DNA helicase -
M2J80_RS28580 (M2J80_28570) 43136..43585 + 450 WP_015026481.1 hypothetical protein -
M2J80_RS28585 (M2J80_28575) 43822..44274 + 453 WP_009684312.1 hypothetical protein -
M2J80_RS28590 (M2J80_28580) 44325..45047 - 723 WP_009684311.1 hypothetical protein -
M2J80_RS28595 (M2J80_28585) 45044..45397 - 354 WP_023118080.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
M2J80_RS28600 (M2J80_28590) 45394..45642 - 249 WP_009684309.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
M2J80_RS28605 (M2J80_28595) 45639..46058 - 420 WP_033690665.1 hypothetical protein -
M2J80_RS28610 (M2J80_28600) 46132..46608 - 477 WP_023118079.1 single-stranded DNA-binding protein -
M2J80_RS28615 (M2J80_28605) 46637..47056 - 420 WP_009683787.1 hypothetical protein -
M2J80_RS28620 (M2J80_28610) 47065..47748 - 684 WP_009683788.1 hypothetical protein -
M2J80_RS28625 (M2J80_28615) 47745..48281 - 537 WP_009683789.1 hypothetical protein -
M2J80_RS28630 (M2J80_28620) 48278..48508 - 231 WP_009683790.1 hypothetical protein -
M2J80_RS28635 (M2J80_28625) 48498..50573 - 2076 WP_009683791.1 DNA cytosine methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..148732 148732


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(11-112)

Antitoxin

SpoVT-AbrB domain

(8-49)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 12146.02 Da        Isoelectric Point: 9.7603

>T244781 WP_023118080.1 NZ_CP097105:c45397-45044 [Pseudomonas sp. NY11382]
MSKRPQHQFDRGDIVSLDMGSASTQVACKALVLSPAAYNALGLALAVPITEHDSSRYAGFAVAIVLPGRTPASGAALVNL
VRPVDLAARGAKLLGKAPQTTIDEALQRLQAVVGKDQ

Download         Length: 354 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8719.94 Da        Isoelectric Point: 4.2668

>AT244781 WP_009684309.1 NZ_CP097105:c45642-45394 [Pseudomonas sp. NY11382]
MKTTIRAIGNSQGITIPKPLLAELGVSLGDPVDVSFKDQTLVVSKVATEYDLSTLVAQCDLEAPEPPDIHCWRTSAPVGN
EA

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2V4KLX1

Antitoxin

Source ID Structure
AlphaFold DB A0A6H1Q8V4

References