Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 297663..298307 Replicon chromosome
Accession NZ_CP097102
Organism Halomonas venusta strain SND-01

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag M3L73_RS01465 Protein ID WP_083001961.1
Coordinates 298125..298307 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag M3L73_RS01460 Protein ID WP_125746403.1
Coordinates 297663..298082 (-) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3L73_RS01430 (M3L73_01430) 293034..293690 + 657 WP_249017362.1 S24 family peptidase -
M3L73_RS01435 (M3L73_01435) 293687..294214 + 528 WP_249017363.1 hypothetical protein -
M3L73_RS01440 (M3L73_01440) 294211..295398 + 1188 WP_249017364.1 DGQHR domain-containing protein -
M3L73_RS01445 (M3L73_01445) 295410..296222 - 813 WP_249017365.1 Dam family site-specific DNA-(adenine-N6)-methyltransferase -
M3L73_RS01450 (M3L73_01450) 296484..296981 - 498 WP_249017366.1 hypothetical protein -
M3L73_RS01455 (M3L73_01455) 297184..297534 + 351 WP_249017367.1 hypothetical protein -
M3L73_RS01460 (M3L73_01460) 297663..298082 - 420 WP_125746403.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
M3L73_RS01465 (M3L73_01465) 298125..298307 - 183 WP_083001961.1 type II toxin-antitoxin system HicA family toxin Toxin
M3L73_RS01470 (M3L73_01470) 298425..299390 - 966 WP_249017368.1 contractile injection system protein, VgrG/Pvc8 family -
M3L73_RS01475 (M3L73_01475) 299393..299842 - 450 WP_249017369.1 phage tail protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 274628..326591 51963


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6641.78 Da        Isoelectric Point: 11.2210

>T244776 WP_083001961.1 NZ_CP097102:c298307-298125 [Halomonas venusta]
VNSRALIKELEADGWELVRVKGSHHHFRHPTKPGTVTVPHPKKDLKTGLVKGIRKSAGLL

Download         Length: 183 bp

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15227.18 Da        Isoelectric Point: 4.3899

>AT244776 WP_125746403.1 NZ_CP097102:c298082-297663 [Halomonas venusta]
MLFPIAIERGDEQHAYGVAVPDLPGCHSAGDTFEEAMTNAKEAIEGWLEVAVDFGDPIPEATSIEHHMDNPDFEGWIWAV
IDIDLTPYLGKSHKINVTLPDLLVKQIDDFVASHPGDKTRSGFLSRVAMAELAKARKSA

Download         Length: 420 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References