Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 39368..39993 Replicon plasmid pEC258-1
Accession NZ_CP097096
Organism Escherichia coli strain 258E

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HPY99_RS22875 Protein ID WP_000911313.1
Coordinates 39368..39766 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID V0VCB2
Locus tag HPY99_RS22880 Protein ID WP_000450520.1
Coordinates 39766..39993 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPY99_RS22860 (35693) 35693..36190 + 498 WP_000605857.1 entry exclusion protein -
HPY99_RS22865 (36222) 36222..36953 + 732 WP_023565183.1 conjugal transfer complement resistance protein TraT -
HPY99_RS22870 (37206) 37206..39359 + 2154 WP_000009324.1 type IV conjugative transfer system coupling protein TraD -
HPY99_RS22875 (39368) 39368..39766 - 399 WP_000911313.1 type II toxin-antitoxin system VapC family toxin Toxin
HPY99_RS22880 (39766) 39766..39993 - 228 WP_000450520.1 toxin-antitoxin system antitoxin VapB Antitoxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..50185 50185


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(8-50)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14901.15 Da        Isoelectric Point: 7.8605

>T244771 WP_000911313.1 NZ_CP097096:c39766-39368 [Escherichia coli]
MLKFMLDTNICIFTIKNKPASVRERFNLNQGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRIDVLDYDAAAATHS
GQIRAELARQGRPVGPFDQMIAGHARSRGLIIVTNNTREFERVDGLRIEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8596.63 Da        Isoelectric Point: 4.7513

>AT244771 WP_000450520.1 NZ_CP097096:c39993-39766 [Escherichia coli]
METTVFFSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAGETWDEWFDGHNVSADFMDNREQPGMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V0VCB2

References