Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 206764..207434 Replicon plasmid pKP130-1
Accession NZ_CP097083
Organism Klebsiella pneumoniae strain KP130

Toxin (Protein)


Gene name vagD Uniprot ID Q6U619
Locus tag M3I82_RS26330 Protein ID WP_004213072.1
Coordinates 206764..207207 (-) Length 148 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID Q6U620
Locus tag M3I82_RS26335 Protein ID WP_004213073.1
Coordinates 207204..207434 (-) Length 77 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3I82_RS26295 (M3I82_26270) 202174..202449 + 276 WP_004213932.1 carboxymuconolactone decarboxylase family protein -
M3I82_RS26300 (M3I82_26275) 202512..203003 + 492 WP_011251327.1 DM13 domain-containing protein -
M3I82_RS26305 (M3I82_26280) 203052..203972 + 921 WP_004213934.1 DUF1471 domain-containing protein -
M3I82_RS26310 (M3I82_26285) 204063..204466 + 404 Protein_223 GAF domain-containing protein -
M3I82_RS26315 (M3I82_26290) 204984..205620 - 637 Protein_224 mucoid phenotype regulator RmpA2 -
M3I82_RS26320 (M3I82_26295) 206037..206341 + 305 Protein_225 transposase -
M3I82_RS26325 (M3I82_26300) 206364..206615 - 252 WP_186987481.1 hypothetical protein -
M3I82_RS26330 (M3I82_26305) 206764..207207 - 444 WP_004213072.1 type II toxin-antitoxin system VapC family toxin Toxin
M3I82_RS26335 (M3I82_26310) 207204..207434 - 231 WP_004213073.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
M3I82_RS26340 (M3I82_26315) 208042..209175 + 1134 WP_004213075.1 DUF3800 domain-containing protein -
M3I82_RS26345 (M3I82_26320) 209191..209484 + 294 WP_004213076.1 hypothetical protein -
M3I82_RS26350 (M3I82_26325) 209474..209680 - 207 WP_004213077.1 hypothetical protein -
M3I82_RS26355 (M3I82_26330) 210032..210322 + 291 WP_004213078.1 hypothetical protein -
M3I82_RS26360 (M3I82_26335) 210312..211211 + 900 WP_004225022.1 nucleotide-binding protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - rmpA / iroN / iroD / iroC / iroB / iucA / iucB / iucC / iucD / iutA / rmpA / rmpA2 1..226565 226565


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(6-129)

Antitoxin

(7-47)


Sequences


Toxin        


Download         Length: 148 a.a.        Molecular weight: 16006.74 Da        Isoelectric Point: 9.3642

>T244766 WP_004213072.1 NZ_CP097083:c207207-206764 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFERVPGLVLEDWVKKAALCRVIS

Download         Length: 444 bp


Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8677.73 Da        Isoelectric Point: 4.4563

>AT244766 WP_004213073.1 NZ_CP097083:c207434-207204 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRAAPDFMAEREDVVSDEGRFEP

Download         Length: 231 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB Q6U619


Antitoxin

Source ID Structure
AlphaFold DB Q6U620

References