Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 169429..170165 Replicon plasmid pKP130-1
Accession NZ_CP097083
Organism Klebsiella pneumoniae strain KP130

Toxin (Protein)


Gene name tacT Uniprot ID A0A2J5Q928
Locus tag M3I82_RS26110 Protein ID WP_004098919.1
Coordinates 169683..170165 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A7D3T1D0
Locus tag M3I82_RS26105 Protein ID WP_004213599.1
Coordinates 169429..169695 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3I82_RS26080 (M3I82_26055) 164661..165218 + 558 WP_004213590.1 recombinase family protein -
M3I82_RS26085 (M3I82_26060) 165221..168190 + 2970 WP_004213592.1 Tn3 family transposase -
M3I82_RS26090 (M3I82_26065) 168232..168726 + 495 WP_004213594.1 hypothetical protein -
M3I82_RS26095 (M3I82_26070) 168787..168990 + 204 WP_004213596.1 HHA domain-containing protein -
M3I82_RS26100 (M3I82_26075) 169004..169234 + 231 WP_004213598.1 hypothetical protein -
M3I82_RS26105 (M3I82_26080) 169429..169695 + 267 WP_004213599.1 DUF1778 domain-containing protein Antitoxin
M3I82_RS26110 (M3I82_26085) 169683..170165 + 483 WP_004098919.1 GNAT family N-acetyltransferase Toxin
M3I82_RS26115 (M3I82_26090) 170586..171813 + 1228 Protein_184 IS3 family transposase -
M3I82_RS26120 (M3I82_26095) 171809..172204 - 396 Protein_185 IS3 family transposase -
M3I82_RS26125 (M3I82_26100) 172379..173401 - 1023 WP_131079334.1 porphobilinogen synthase -
M3I82_RS26130 (M3I82_26105) 173465..174811 - 1347 WP_011154555.1 dihydroorotase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - rmpA / iroN / iroD / iroC / iroB / iucA / iucB / iucC / iucD / iutA / rmpA / rmpA2 1..226565 226565
- inside IScluster/Tn - - 164661..171813 7152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(66-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17335.06 Da        Isoelectric Point: 10.0704

>T244765 WP_004098919.1 NZ_CP097083:169683-170165 [Klebsiella pneumoniae]
VGRITAPEPLSSAHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKKGTKKVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYAHHGFKASQTHERTLFLKLP

Download         Length: 483 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10151.58 Da        Isoelectric Point: 4.5141

>AT244765 WP_004213599.1 NZ_CP097083:169429-169695 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRVLIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDDSAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J5Q928

Antitoxin

Source ID Structure
AlphaFold DB A0A7D3T1D0

References