Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/ElaA-DUF1778
Location 23661..24412 Replicon plasmid pKP130-1
Accession NZ_CP097083
Organism Klebsiella pneumoniae strain KP130

Toxin (Protein)


Gene name ataT Uniprot ID -
Locus tag M3I82_RS25315 Protein ID WP_004902249.1
Coordinates 23661..24143 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A071LPN3
Locus tag M3I82_RS25320 Protein ID WP_004902250.1
Coordinates 24134..24412 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3I82_RS25295 (M3I82_25275) 20060..20707 - 648 WP_014386537.1 EcsC family protein -
M3I82_RS25300 (M3I82_25280) 20734..21489 - 756 WP_004902235.1 DUF2971 domain-containing protein -
M3I82_RS25305 (M3I82_25285) 21590..21982 - 393 WP_045145491.1 hypothetical protein -
M3I82_RS25310 (M3I82_25290) 22087..22626 - 540 WP_004902239.1 hypothetical protein -
M3I82_RS25315 (M3I82_25295) 23661..24143 - 483 WP_004902249.1 GNAT family N-acetyltransferase Toxin
M3I82_RS25320 (M3I82_25300) 24134..24412 - 279 WP_004902250.1 DUF1778 domain-containing protein Antitoxin
M3I82_RS25325 (M3I82_25305) 24531..24743 - 213 WP_266051389.1 hypothetical protein -
M3I82_RS25330 (M3I82_25310) 24851..25192 - 342 WP_004902257.1 hypothetical protein -
M3I82_RS25335 25785..25931 - 147 Protein_28 DUF2235 domain-containing protein -
M3I82_RS25340 (M3I82_25320) 25966..26076 + 111 Protein_29 glutathione ABC transporter permease GsiC -
M3I82_RS25345 (M3I82_25325) 26160..27830 - 1671 WP_004902261.1 AMP-binding protein -
M3I82_RS25350 (M3I82_25330) 27811..29076 - 1266 WP_004210292.1 MSMEG_0569 family flavin-dependent oxidoreductase -
M3I82_RS25355 (M3I82_25335) 29094..29384 - 291 WP_011154627.1 MSMEG_0570 family nitrogen starvation response protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - rmpA / iroN / iroD / iroC / iroB / iucA / iucB / iucC / iucD / iutA / rmpA / rmpA2 1..226565 226565


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-144)

Antitoxin

Vibrio phage ICP1, Orf50

(10-86)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17689.52 Da        Isoelectric Point: 9.2033

>T244763 WP_004902249.1 NZ_CP097083:c24143-23661 [Klebsiella pneumoniae]
MGMRAPESLTAEHNIAEFCCQEPALNEWLKKKALRNHSTGISRVYVVCAENTNRVIGYYCLSSGSVHRNKVPGAYRRNAP
DVIPVIVLGRLAIDQAWAGNGLGAALLKDAIYRTQNIAFQVGVRALAVHALNEEVKCFYTRFGFEPSIVNTLTLLFPIKV

Download         Length: 483 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10704.23 Da        Isoelectric Point: 4.5271

>AT244763 WP_004902250.1 NZ_CP097083:c24412-24134 [Klebsiella pneumoniae]
MKPDVREAPINIRAKTSQRDLIDMAASLVSKSRTDFMLEVACREAQDILLDQRLFLLNDNQFEAFIEELDAPITPERQAR
IDNLMNRKSPWE

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A071LPN3

References