Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 4819705..4821386 Replicon chromosome
Accession NZ_CP097082
Organism Klebsiella pneumoniae strain KP130

Toxin (Protein)


Gene name mosT Uniprot ID J2XCI1
Locus tag M3I82_RS23315 Protein ID WP_004146663.1
Coordinates 4819705..4820622 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A6TH05
Locus tag M3I82_RS23320 Protein ID WP_004177809.1
Coordinates 4820628..4821386 (-) Length 253 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3I82_RS23295 (4815011) 4815011..4816531 + 1521 WP_004210021.1 sugar ABC transporter ATP-binding protein -
M3I82_RS23300 (4816528) 4816528..4817526 + 999 WP_002885172.1 ribose ABC transporter permease -
M3I82_RS23305 (4817557) 4817557..4818498 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
M3I82_RS23310 (4818573) 4818573..4819580 + 1008 WP_269897269.1 carbohydrate kinase family protein -
M3I82_RS23315 (4819705) 4819705..4820622 - 918 WP_004146663.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
M3I82_RS23320 (4820628) 4820628..4821386 - 759 WP_004177809.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
M3I82_RS23325 (4821472) 4821472..4822200 - 729 WP_004177810.1 response regulator transcription factor -
M3I82_RS23330 (4822473) 4822473..4824620 + 2148 WP_012737173.1 formate dehydrogenase H subunit alpha, selenocysteine-containing -
M3I82_RS23335 (4824617) 4824617..4824760 - 144 WP_022631365.1 hypothetical protein -
M3I82_RS23340 (4824966) 4824966..4825652 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 306 a.a.        Molecular weight: 34659.10 Da        Isoelectric Point: 5.4707

>T244761 WP_004146663.1 NZ_CP097082:c4820622-4819705 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp


Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28548.92 Da        Isoelectric Point: 10.0870

>AT244761 WP_004177809.1 NZ_CP097082:c4821386-4820628 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB J2XCI1


Antitoxin

Source ID Structure
AlphaFold DB A6TH05

References