Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | mosAT/AbiEii-AbiEi |
Location | 4819705..4821386 | Replicon | chromosome |
Accession | NZ_CP097082 | ||
Organism | Klebsiella pneumoniae strain KP130 |
Toxin (Protein)
Gene name | mosT | Uniprot ID | J2XCI1 |
Locus tag | M3I82_RS23315 | Protein ID | WP_004146663.1 |
Coordinates | 4819705..4820622 (-) | Length | 306 a.a. |
Antitoxin (Protein)
Gene name | mosA | Uniprot ID | A6TH05 |
Locus tag | M3I82_RS23320 | Protein ID | WP_004177809.1 |
Coordinates | 4820628..4821386 (-) | Length | 253 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
M3I82_RS23295 (4815011) | 4815011..4816531 | + | 1521 | WP_004210021.1 | sugar ABC transporter ATP-binding protein | - |
M3I82_RS23300 (4816528) | 4816528..4817526 | + | 999 | WP_002885172.1 | ribose ABC transporter permease | - |
M3I82_RS23305 (4817557) | 4817557..4818498 | + | 942 | WP_002885156.1 | ABC transporter substrate-binding protein | - |
M3I82_RS23310 (4818573) | 4818573..4819580 | + | 1008 | WP_269897269.1 | carbohydrate kinase family protein | - |
M3I82_RS23315 (4819705) | 4819705..4820622 | - | 918 | WP_004146663.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
M3I82_RS23320 (4820628) | 4820628..4821386 | - | 759 | WP_004177809.1 | type IV toxin-antitoxin system AbiEi family antitoxin | Antitoxin |
M3I82_RS23325 (4821472) | 4821472..4822200 | - | 729 | WP_004177810.1 | response regulator transcription factor | - |
M3I82_RS23330 (4822473) | 4822473..4824620 | + | 2148 | WP_012737173.1 | formate dehydrogenase H subunit alpha, selenocysteine-containing | - |
M3I82_RS23335 (4824617) | 4824617..4824760 | - | 144 | WP_022631365.1 | hypothetical protein | - |
M3I82_RS23340 (4824966) | 4824966..4825652 | + | 687 | WP_004151733.1 | tetratricopeptide repeat protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 306 a.a. Molecular weight: 34659.10 Da Isoelectric Point: 5.4707
>T244761 WP_004146663.1 NZ_CP097082:c4820622-4819705 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS
Download Length: 918 bp
Antitoxin
Download Length: 253 a.a. Molecular weight: 28548.92 Da Isoelectric Point: 10.0870
>AT244761 WP_004177809.1 NZ_CP097082:c4821386-4820628 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE
Download Length: 759 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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