Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4674934..4675450 Replicon chromosome
Accession NZ_CP097082
Organism Klebsiella pneumoniae strain KP130

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag M3I82_RS22565 Protein ID WP_009486548.1
Coordinates 4674934..4675218 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag M3I82_RS22570 Protein ID WP_002886901.1
Coordinates 4675208..4675450 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3I82_RS22540 (4670330) 4670330..4670593 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
M3I82_RS22545 (4670723) 4670723..4670896 + 174 WP_004222159.1 hypothetical protein -
M3I82_RS22550 (4670899) 4670899..4671642 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
M3I82_RS22555 (4671999) 4671999..4674137 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
M3I82_RS22560 (4674466) 4674466..4674930 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
M3I82_RS22565 (4674934) 4674934..4675218 - 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M3I82_RS22570 (4675208) 4675208..4675450 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
M3I82_RS22575 (4675528) 4675528..4677438 - 1911 WP_004152270.1 PRD domain-containing protein -
M3I82_RS22580 (4677461) 4677461..4678615 - 1155 WP_004178372.1 lactonase family protein -
M3I82_RS22585 (4678682) 4678682..4679422 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T244760 WP_009486548.1 NZ_CP097082:c4675218-4674934 [Klebsiella pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT244760 WP_002886901.1 NZ_CP097082:c4675450-4675208 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References