Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 811388..812045 Replicon chromosome
Accession NZ_CP097082
Organism Klebsiella pneumoniae strain KP130

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag M3I82_RS04025 Protein ID WP_002916310.1
Coordinates 811635..812045 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag M3I82_RS04020 Protein ID WP_002916312.1
Coordinates 811388..811654 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3I82_RS03995 (807031) 807031..807717 - 687 WP_131079352.1 MurR/RpiR family transcriptional regulator -
M3I82_RS04000 (807751) 807751..808719 + 969 WP_004225014.1 IS5 family transposase -
M3I82_RS04005 (808874) 808874..809185 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
M3I82_RS04010 (809349) 809349..810008 + 660 WP_002916317.1 hemolysin III family protein -
M3I82_RS04015 (810159) 810159..811142 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
M3I82_RS04020 (811388) 811388..811654 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
M3I82_RS04025 (811635) 811635..812045 + 411 WP_002916310.1 protein YgfX Toxin
M3I82_RS04030 (812052) 812052..812573 - 522 WP_002916308.1 flavodoxin FldB -
M3I82_RS04035 (812674) 812674..813570 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
M3I82_RS04040 (813593) 813593..814306 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
M3I82_RS04045 (814312) 814312..816045 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 807796..808719 923


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T244751 WP_002916310.1 NZ_CP097082:811635-812045 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT244751 WP_002916312.1 NZ_CP097082:811388-811654 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References