Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 193565..194301 Replicon plasmid pKP131-1
Accession NZ_CP097080
Organism Klebsiella pneumoniae strain KP131

Toxin (Protein)


Gene name tacT Uniprot ID A0A2J5Q928
Locus tag M3I83_RS26280 Protein ID WP_004098919.1
Coordinates 193565..194047 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A7D3T1D0
Locus tag M3I83_RS26285 Protein ID WP_004213599.1
Coordinates 194035..194301 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3I83_RS26260 (M3I83_26235) 188919..190265 + 1347 WP_011154555.1 dihydroorotase -
M3I83_RS26265 (M3I83_26240) 190329..191351 + 1023 WP_131079334.1 porphobilinogen synthase -
M3I83_RS26270 (M3I83_26245) 191526..191921 + 396 Protein_215 IS3 family transposase -
M3I83_RS26275 (M3I83_26250) 191917..193144 - 1228 Protein_216 IS3 family transposase -
M3I83_RS26280 (M3I83_26255) 193565..194047 - 483 WP_004098919.1 GNAT family N-acetyltransferase Toxin
M3I83_RS26285 (M3I83_26260) 194035..194301 - 267 WP_004213599.1 DUF1778 domain-containing protein Antitoxin
M3I83_RS26290 (M3I83_26265) 194496..194726 - 231 WP_004213598.1 hypothetical protein -
M3I83_RS26295 (M3I83_26270) 194740..194943 - 204 WP_004213596.1 HHA domain-containing protein -
M3I83_RS26300 (M3I83_26275) 195004..195498 - 495 WP_004213594.1 hypothetical protein -
M3I83_RS26305 (M3I83_26280) 195540..198509 - 2970 WP_004213592.1 Tn3 family transposase -
M3I83_RS26310 (M3I83_26285) 198512..199069 - 558 WP_004213590.1 recombinase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - iroB / iroC / iroD / iroN / rmpA / rmpA2 / rmpA / iutA / iucD / iucC / iucB / iucA 1..226558 226558
- inside IScluster/Tn - - 191917..199069 7152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(66-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17335.06 Da        Isoelectric Point: 10.0704

>T244748 WP_004098919.1 NZ_CP097080:c194047-193565 [Klebsiella pneumoniae]
VGRITAPEPLSSAHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKKGTKKVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYAHHGFKASQTHERTLFLKLP

Download         Length: 483 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10151.58 Da        Isoelectric Point: 4.5141

>AT244748 WP_004213599.1 NZ_CP097080:c194301-194035 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRVLIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDDSAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J5Q928

Antitoxin

Source ID Structure
AlphaFold DB A0A7D3T1D0

References