Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2598526..2600114 Replicon chromosome
Accession NZ_CP097079
Organism Klebsiella pneumoniae strain KP131

Toxin (Protein)


Gene name hipA Uniprot ID W9B834
Locus tag M3I83_RS12640 Protein ID WP_016529318.1
Coordinates 2598526..2599848 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A483IVM3
Locus tag M3I83_RS12645 Protein ID WP_029496892.1
Coordinates 2599848..2600114 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3I83_RS12625 (2593582) 2593582..2596083 + 2502 WP_032410312.1 fimbria/pilus outer membrane usher protein -
M3I83_RS12630 (2596071) 2596071..2597075 + 1005 WP_009485243.1 fimbrial protein -
M3I83_RS12635 (2597217) 2597217..2598509 + 1293 WP_131079278.1 glycoside hydrolase family 10 protein -
M3I83_RS12640 (2598526) 2598526..2599848 - 1323 WP_016529318.1 type II toxin-antitoxin system HipA family toxin Toxin
M3I83_RS12645 (2599848) 2599848..2600114 - 267 WP_029496892.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
M3I83_RS12650 (2600501) 2600501..2600827 - 327 WP_002904788.1 hydroxyisourate hydrolase -
M3I83_RS12655 (2600824) 2600824..2601324 - 501 WP_020804988.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
M3I83_RS12660 (2601302) 2601302..2602681 - 1380 WP_020804975.1 nucleobase:cation symporter-2 family protein -
M3I83_RS12665 (2603027) 2603027..2604181 + 1155 WP_020804972.1 FAD-dependent urate hydroxylase HpxO -
M3I83_RS12670 (2604162) 2604162..2605085 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-64)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49125.44 Da        Isoelectric Point: 7.5366

>T244738 WP_016529318.1 NZ_CP097079:c2599848-2598526 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEFLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9938.33 Da        Isoelectric Point: 8.5912

>AT244738 WP_029496892.1 NZ_CP097079:c2600114-2599848 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGMVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB W9B834

Antitoxin

Source ID Structure
AlphaFold DB A0A483IVM3

References