Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/ElaA-DUF1778
Location 112753..113504 Replicon plasmid pKP133-1
Accession NZ_CP097077
Organism Klebsiella pneumoniae strain KP133

Toxin (Protein)


Gene name ataT Uniprot ID -
Locus tag M3I84_RS25845 Protein ID WP_004902249.1
Coordinates 113022..113504 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A071LPN3
Locus tag M3I84_RS25840 Protein ID WP_004902250.1
Coordinates 112753..113031 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3I84_RS25805 (M3I84_25775) 107781..108071 + 291 WP_011154627.1 MSMEG_0570 family nitrogen starvation response protein -
M3I84_RS25810 (M3I84_25780) 108089..109354 + 1266 WP_004210292.1 MSMEG_0569 family flavin-dependent oxidoreductase -
M3I84_RS25815 (M3I84_25785) 109335..111005 + 1671 WP_004902261.1 AMP-binding protein -
M3I84_RS25820 (M3I84_25790) 111089..111199 - 111 Protein_124 glutathione ABC transporter permease GsiC -
M3I84_RS25825 111234..111380 + 147 Protein_125 DUF2235 domain-containing protein -
M3I84_RS25830 (M3I84_25800) 111973..112314 + 342 WP_004902257.1 hypothetical protein -
M3I84_RS25835 (M3I84_25805) 112422..112634 + 213 WP_266051389.1 hypothetical protein -
M3I84_RS25840 (M3I84_25810) 112753..113031 + 279 WP_004902250.1 DUF1778 domain-containing protein Antitoxin
M3I84_RS25845 (M3I84_25815) 113022..113504 + 483 WP_004902249.1 GNAT family N-acetyltransferase Toxin
M3I84_RS25850 (M3I84_25820) 114539..115078 + 540 WP_004902239.1 hypothetical protein -
M3I84_RS25855 (M3I84_25825) 115183..115575 + 393 WP_045145491.1 hypothetical protein -
M3I84_RS25860 (M3I84_25830) 115676..116431 + 756 WP_004902235.1 DUF2971 domain-containing protein -
M3I84_RS25865 (M3I84_25835) 116458..117105 + 648 WP_014386537.1 EcsC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid aac(6')-Ib-cr / ARR-3 / blaKPC-2 / dfrA14 iroB / iroC / iroD / iroN / rmpA / rmpA2 / rmpA / iutA / iucD / iucC / iucB / iucA 1..296587 296587


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-144)

Antitoxin

Vibrio phage ICP1, Orf50

(10-86)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17689.52 Da        Isoelectric Point: 9.2033

>T244728 WP_004902249.1 NZ_CP097077:113022-113504 [Klebsiella pneumoniae]
MGMRAPESLTAEHNIAEFCCQEPALNEWLKKKALRNHSTGISRVYVVCAENTNRVIGYYCLSSGSVHRNKVPGAYRRNAP
DVIPVIVLGRLAIDQAWAGNGLGAALLKDAIYRTQNIAFQVGVRALAVHALNEEVKCFYTRFGFEPSIVNTLTLLFPIKV

Download         Length: 483 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10704.23 Da        Isoelectric Point: 4.5271

>AT244728 WP_004902250.1 NZ_CP097077:112753-113031 [Klebsiella pneumoniae]
MKPDVREAPINIRAKTSQRDLIDMAASLVSKSRTDFMLEVACREAQDILLDQRLFLLNDNQFEAFIEELDAPITPERQAR
IDNLMNRKSPWE

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A071LPN3

References