Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4674794..4675310 Replicon chromosome
Accession NZ_CP097076
Organism Klebsiella pneumoniae strain KP133

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag M3I84_RS22570 Protein ID WP_009486548.1
Coordinates 4674794..4675078 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag M3I84_RS22575 Protein ID WP_002886901.1
Coordinates 4675068..4675310 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3I84_RS22545 (4670190) 4670190..4670453 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
M3I84_RS22550 (4670583) 4670583..4670756 + 174 WP_004222159.1 hypothetical protein -
M3I84_RS22555 (4670759) 4670759..4671502 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
M3I84_RS22560 (4671859) 4671859..4673997 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
M3I84_RS22565 (4674326) 4674326..4674790 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
M3I84_RS22570 (4674794) 4674794..4675078 - 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M3I84_RS22575 (4675068) 4675068..4675310 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
M3I84_RS22580 (4675388) 4675388..4677298 - 1911 WP_004152270.1 PRD domain-containing protein -
M3I84_RS22585 (4677321) 4677321..4678475 - 1155 WP_004178372.1 lactonase family protein -
M3I84_RS22590 (4678542) 4678542..4679282 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T244724 WP_009486548.1 NZ_CP097076:c4675078-4674794 [Klebsiella pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT244724 WP_002886901.1 NZ_CP097076:c4675310-4675068 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References