Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2598506..2600094 Replicon chromosome
Accession NZ_CP097076
Organism Klebsiella pneumoniae strain KP133

Toxin (Protein)


Gene name hipA Uniprot ID W9B834
Locus tag M3I84_RS12645 Protein ID WP_016529318.1
Coordinates 2598506..2599828 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A483IVM3
Locus tag M3I84_RS12650 Protein ID WP_029496892.1
Coordinates 2599828..2600094 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3I84_RS12630 (2593562) 2593562..2596063 + 2502 WP_032410312.1 fimbria/pilus outer membrane usher protein -
M3I84_RS12635 (2596051) 2596051..2597055 + 1005 WP_009485243.1 fimbrial protein -
M3I84_RS12640 (2597197) 2597197..2598489 + 1293 WP_131079278.1 glycoside hydrolase family 10 protein -
M3I84_RS12645 (2598506) 2598506..2599828 - 1323 WP_016529318.1 type II toxin-antitoxin system HipA family toxin Toxin
M3I84_RS12650 (2599828) 2599828..2600094 - 267 WP_029496892.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
M3I84_RS12655 (2600481) 2600481..2600807 - 327 WP_002904788.1 hydroxyisourate hydrolase -
M3I84_RS12660 (2600804) 2600804..2601304 - 501 WP_020804988.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
M3I84_RS12665 (2601282) 2601282..2602661 - 1380 WP_020804975.1 nucleobase:cation symporter-2 family protein -
M3I84_RS12670 (2603007) 2603007..2604161 + 1155 WP_020804972.1 FAD-dependent urate hydroxylase HpxO -
M3I84_RS12675 (2604142) 2604142..2605065 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-64)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49125.44 Da        Isoelectric Point: 7.5366

>T244720 WP_016529318.1 NZ_CP097076:c2599828-2598506 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEFLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9938.33 Da        Isoelectric Point: 8.5912

>AT244720 WP_029496892.1 NZ_CP097076:c2600094-2599828 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGMVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB W9B834

Antitoxin

Source ID Structure
AlphaFold DB A0A483IVM3

References