Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 811252..811909 Replicon chromosome
Accession NZ_CP097076
Organism Klebsiella pneumoniae strain KP133

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag M3I84_RS04025 Protein ID WP_002916310.1
Coordinates 811499..811909 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag M3I84_RS04020 Protein ID WP_002916312.1
Coordinates 811252..811518 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3I84_RS03995 (806895) 806895..807581 - 687 WP_131079352.1 MurR/RpiR family transcriptional regulator -
M3I84_RS04000 (807615) 807615..808583 + 969 WP_004225014.1 IS5 family transposase -
M3I84_RS04005 (808738) 808738..809049 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
M3I84_RS04010 (809213) 809213..809872 + 660 WP_002916317.1 hemolysin III family protein -
M3I84_RS04015 (810023) 810023..811006 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
M3I84_RS04020 (811252) 811252..811518 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
M3I84_RS04025 (811499) 811499..811909 + 411 WP_002916310.1 protein YgfX Toxin
M3I84_RS04030 (811916) 811916..812437 - 522 WP_002916308.1 flavodoxin FldB -
M3I84_RS04035 (812538) 812538..813434 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
M3I84_RS04040 (813457) 813457..814170 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
M3I84_RS04045 (814176) 814176..815909 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 807660..808583 923


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T244715 WP_002916310.1 NZ_CP097076:811499-811909 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT244715 WP_002916312.1 NZ_CP097076:811252-811518 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References