Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Xre-MNT/HTH_26(antitoxin)
Location 1087301..1088409 Replicon chromosome
Accession NZ_CP097072
Organism Vagococcus lutrae strain AT03

Toxin (Protein)


Gene name MNTss Uniprot ID A0A0M4MHJ8
Locus tag M2901_RS05390 Protein ID WP_002303392.1
Coordinates 1087540..1088409 (+) Length 290 a.a.

Antitoxin (Protein)


Gene name Xress Uniprot ID B9DSK1
Locus tag M2901_RS05385 Protein ID WP_002303393.1
Coordinates 1087301..1087525 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2901_RS05365 (M2901_05365) 1082431..1082865 + 435 WP_002325146.1 hypothetical protein -
M2901_RS05370 (M2901_05370) 1083308..1084792 + 1485 WP_002294513.1 ABC-F type ribosomal protection protein Lsa(E) -
M2901_RS05375 (M2901_05375) 1084846..1085649 + 804 WP_002294514.1 lincosamide nucleotidyltransferase Lnu(B) -
M2901_RS05380 (M2901_05380) 1086337..1087158 + 822 Protein_1025 recombinase zinc beta ribbon domain-containing protein -
M2901_RS05385 (M2901_05385) 1087301..1087525 + 225 WP_002303393.1 helix-turn-helix transcriptional regulator Antitoxin
M2901_RS05390 (M2901_05390) 1087540..1088409 + 870 WP_002303392.1 nucleotidyltransferase domain-containing protein Toxin
M2901_RS05395 (M2901_05395) 1088390..1089124 + 735 WP_000662263.1 class I SAM-dependent methyltransferase -
M2901_RS05400 (M2901_05400) 1089157..1090020 + 864 WP_002294505.1 aminoglycoside nucleotidyltransferase ANT(6)-Ia -
M2901_RS05405 (M2901_05405) 1090064..1090591 + 528 WP_002294507.1 phosphoribosyltransferase family protein -
M2901_RS05410 (M2901_05410) 1090819..1091325 + 507 Protein_1031 transposase -
M2901_RS05415 (M2901_05415) 1091381..1092061 - 681 WP_002323195.1 IS6 family transposase -
M2901_RS05420 (M2901_05420) 1092215..1092895 - 681 WP_001015311.1 IS6-like element IS1216 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polymerase, nucleotidyl transferase domain

(12-111)

Antitoxin

Cro/C1-type helix-turn-helix domain

(4-57)


Sequences

Toxin        


Download         Length: 290 a.a.        Molecular weight: 32807.38 Da        Isoelectric Point: 4.7269

>T244712 WP_002303392.1 NZ_CP097072:1087540-1088409 [Vagococcus lutrae]
MVGNVIQIVTEKLSSLPFIEGIVLGGSRARSTHTENSDIDIGIYYNSDSFDLTAINQIATELDDENRNNLVVPPGAWGDW
VNGGGWLVINGCHVDLILRDIKRVEQIIKDTEQGIVTANYQTGHPHGYISAMYRGELAISKILYAKNESLCELKKQAEIY
PTALKKSLMNFFIFEAEFSLMFVKANAGAEDKYYIAGHVFRIISCLNQVLFACNNAYCINEKKAIKLLETFEYKPEKYAE
RVNHIFEVLGLSLFECYDMTEKLYKEVNEIVSEINNFLNEESSDERKQI

Download         Length: 870 bp

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8351.65 Da        Isoelectric Point: 4.5357

>AT244712 WP_002303393.1 NZ_CP097072:1087301-1087525 [Vagococcus lutrae]
MTTAEMIKELCEQMNISVSELARRIGQTPQNFNKKLQRETVTLDELKAIADVLGVKFVQAFILPDGDEIKISNE

Download         Length: 225 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M4MHJ8

Antitoxin

Source ID Structure
AlphaFold DB A0A1M5SHM7

References