244711

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 48142..48724 Replicon plasmid pAT40a-b
Accession NZ_CP097071
Organism Enterococcus faecalis strain AT40a

Toxin (Protein)


Gene name zeta Uniprot ID A0A0M2AE74
Locus tag M2912_RS13830 Protein ID WP_002355414.1
Coordinates 48416..48724 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID Q9AL19
Locus tag M2912_RS13825 Protein ID WP_002326825.1
Coordinates 48142..48414 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2912_RS13795 (M2912_13795) 43265..43618 + 354 WP_283162988.1 DUF805 domain-containing protein -
M2912_RS13800 (M2912_13800) 43671..44183 + 513 WP_002387940.1 transposase -
M2912_RS13805 (M2912_13805) 44180..45217 + 1038 WP_002303110.1 IS3 family transposase -
M2912_RS13815 (M2912_13815) 46985..47839 + 855 WP_248868129.1 ParA family protein -
M2912_RS13820 (M2912_13820) 47910..48125 + 216 WP_002355411.1 peptide-binding protein -
M2912_RS13825 (M2912_13825) 48142..48414 + 273 WP_002326825.1 antitoxin Antitoxin
M2912_RS13830 (M2912_13830) 48416..48724 + 309 WP_002355414.1 zeta toxin family protein Toxin
M2912_RS13835 (M2912_13835) 48804..49226 - 423 WP_080005963.1 tyrosine-type recombinase/integrase -
M2912_RS13840 (M2912_13840) 49277..49777 - 501 WP_002355415.1 HAD family hydrolase -
M2912_RS13845 (M2912_13845) 49782..50549 - 768 WP_002355416.1 DeoR/GlpR family DNA-binding transcription regulator -
M2912_RS13850 (M2912_13850) 51037..51462 + 426 WP_002355418.1 galactose-6-phosphate isomerase subunit LacA -
M2912_RS13855 (M2912_13855) 51479..51994 + 516 WP_002345825.1 galactose-6-phosphate isomerase subunit LacB -
M2912_RS13860 (M2912_13860) 52005..52937 + 933 WP_002363040.1 tagatose-6-phosphate kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - prgB/asc10 / bsh 1..76993 76993


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-99)

Antitoxin

Bacterial epsilon antitoxin

(2-90)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11525.91 Da        Isoelectric Point: 5.7251

>T244711 WP_002355414.1 NZ_CP097071:48416-48724 [Enterococcus faecalis]
MANITDFTEKQFEDRLEKNVERLTKNRLAVESPTAFLLGGQPGSGKTSLRSAISEETQGNVVIIDNDTFKQQHPNFDELV
KLYEKDVVKHATSYSNQLVKLN

Download         Length: 309 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10720.17 Da        Isoelectric Point: 4.4865

>AT244711 WP_002326825.1 NZ_CP097071:48142-48414 [Enterococcus faecalis]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELDTKNTRLLEVNLLNQLEVAQEVDLFQQPFEELQAIHEYWRSMNQYS
KQILTKEKVA

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2AE74

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2AF93

References