Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-dinJ/YafQ-DinJ
Location 34647..35181 Replicon plasmid pAT40a-b
Accession NZ_CP097071
Organism Enterococcus faecalis strain AT40a

Toxin (Protein)


Gene name relE Uniprot ID R3JX52
Locus tag M2912_RS13745 Protein ID WP_002360769.1
Coordinates 34906..35181 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID R3H6P0
Locus tag M2912_RS13740 Protein ID WP_002369771.1
Coordinates 34647..34913 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2912_RS13710 (M2912_13710) 30750..31535 + 786 WP_000803546.1 winged helix-turn-helix domain-containing protein -
M2912_RS13715 (M2912_13715) 31541..32029 + 489 WP_002368088.1 hypothetical protein -
M2912_RS13720 (M2912_13720) 32621..32887 + 267 WP_002368091.1 hypothetical protein -
M2912_RS13725 (M2912_13725) 32920..33414 + 495 WP_002368092.1 DnaJ domain-containing protein -
M2912_RS13730 (M2912_13730) 33512..33928 + 417 WP_248868131.1 single-stranded DNA-binding protein -
M2912_RS13735 (M2912_13735) 33952..34536 + 585 WP_002368095.1 thermonuclease family protein -
M2912_RS13740 (M2912_13740) 34647..34913 + 267 WP_002369771.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
M2912_RS13745 (M2912_13745) 34906..35181 + 276 WP_002360769.1 type II toxin-antitoxin system YafQ family toxin Toxin
M2912_RS13750 (M2912_13750) 35984..36169 + 186 WP_002368099.1 hypothetical protein -
M2912_RS13755 (M2912_13755) 36154..36345 + 192 WP_002401572.1 DpnD/PcfM family protein -
M2912_RS13760 (M2912_13760) 36576..37355 + 780 WP_002402212.1 Cas9 inhibitor AcrIIA9 family protein -
M2912_RS13765 (M2912_13765) 37355..38614 + 1260 WP_002402213.1 PcfJ domain-containing protein -
M2912_RS13770 (M2912_13770) 39264..39992 + 729 WP_002402215.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - prgB/asc10 / bsh 1..76993 76993


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(7-86)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10732.58 Da        Isoelectric Point: 9.6918

>T244710 WP_002360769.1 NZ_CP097071:34906-35181 [Enterococcus faecalis]
MLEIFYTNQFKKDFKKAKKQGKNLEKLKEVLVLLQEQQTLPPKYKDHALTGNYIGTRECHIEPDWLLIYKIDGDKLILTL
ARIGSHSELFR

Download         Length: 276 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9772.09 Da        Isoelectric Point: 4.4791

>AT244710 WP_002369771.1 NZ_CP097071:34647-34913 [Enterococcus faecalis]
VATTKKKPIHVNVDENLKEEAEQLFDDLGLNMTSAITIFLKQSINEQAIPFMINKGNKETLQALKDIKEGNVHGGFSSVE
DLMEDLNA

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2AEA7

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2AED7

References