Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 2637230..2637801 Replicon chromosome
Accession NZ_CP097069
Organism Enterococcus faecalis strain AT40a

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag M2912_RS12685 Protein ID WP_010710856.1
Coordinates 2637230..2637571 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID R3JGB1
Locus tag M2912_RS12690 Protein ID WP_002354773.1
Coordinates 2637571..2637801 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2912_RS12680 (2633245) 2633245..2636859 - 3615 WP_002389470.1 DNA-directed RNA polymerase subunit beta -
M2912_RS12685 (2637230) 2637230..2637571 - 342 WP_010710856.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
M2912_RS12690 (2637571) 2637571..2637801 - 231 WP_002354773.1 hypothetical protein Antitoxin
M2912_RS12695 (2638132) 2638132..2638347 - 216 WP_002354768.1 zinc ribbon domain-containing protein -
M2912_RS12700 (2638486) 2638486..2639478 + 993 WP_002394775.1 biotin--[acetyl-CoA-carboxylase] ligase -
M2912_RS12705 (2639645) 2639645..2640283 - 639 WP_002378863.1 lytic polysaccharide monooxygenase -
M2912_RS12710 (2640968) 2640968..2642584 + 1617 WP_010710855.1 phosphatase PAP2/LCP family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13177.47 Da        Isoelectric Point: 9.3988

>T244702 WP_010710856.1 NZ_CP097069:c2637571-2637230 [Enterococcus faecalis]
MNVEKKYIPKKGDIVWIDFDPAAGKEIQKRRPGLVVSRYEFNRKTMFAVICPIISTIKNIPTRYTLPDDIETHGQVVISQ
LKSLDFTERKLSQIEHLPLKDMAKIDQIIEYIF

Download         Length: 342 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8677.67 Da        Isoelectric Point: 4.3313

>AT244702 WP_002354773.1 NZ_CP097069:c2637801-2637571 [Enterococcus faecalis]
MLTTKSRRQGSSVVLTLPTDNGKKPKVDQEYIVMYSDDGTITLVPKIQDPFSEGPEGEYYEKDEWHDLAPEGRELF

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2A812

References