Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Xre-MNT/HTH_26(antitoxin)
Location 1360033..1361141 Replicon chromosome
Accession NZ_CP097069
Organism Enterococcus faecalis strain AT40a

Toxin (Protein)


Gene name MNTss Uniprot ID A0A193AUR0
Locus tag M2912_RS06550 Protein ID WP_002378351.1
Coordinates 1360033..1360902 (-) Length 290 a.a.

Antitoxin (Protein)


Gene name Xress Uniprot ID -
Locus tag M2912_RS06555 Protein ID WP_000205227.1
Coordinates 1360917..1361141 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2912_RS06530 (1356304) 1356304..1357623 - 1320 WP_002338419.1 IS1380-like element ISSsu5 family transposase -
M2912_RS06535 (1357851) 1357851..1358252 - 402 WP_002401582.1 phosphoribosyltransferase family protein -
M2912_RS06540 (1358422) 1358422..1359285 - 864 WP_002294505.1 aminoglycoside nucleotidyltransferase ANT(6)-Ia -
M2912_RS06545 (1359318) 1359318..1360052 - 735 WP_000662263.1 class I SAM-dependent methyltransferase -
M2912_RS06550 (1360033) 1360033..1360902 - 870 WP_002378351.1 nucleotidyltransferase domain-containing protein Toxin
M2912_RS06555 (1360917) 1360917..1361141 - 225 WP_000205227.1 helix-turn-helix transcriptional regulator Antitoxin
M2912_RS06560 (1361284) 1361284..1361370 - 87 Protein_1261 site-specific recombinase -
M2912_RS06565 (1361559) 1361559..1362860 + 1302 Protein_1262 ISL3 family transposase -
M2912_RS06570 (1363169) 1363169..1363972 - 804 WP_002294514.1 lincosamide nucleotidyltransferase Lnu(B) -
M2912_RS06575 (1364026) 1364026..1365510 - 1485 WP_002294513.1 ABC-F type ribosomal protection protein Lsa(E) -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element erm(B) / ant(6)-Ia / lnu(B) / lsa(E) / aph(3')-III / aac(6')-aph(2'') - 1189036..1410933 221897
- inside IScluster/Tn erm(B) / ant(6)-Ia / lnu(B) / lsa(E) / aph(3')-III / aac(6')-aph(2'') - 1348642..1379331 30689


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polymerase, nucleotidyl transferase domain

(12-111)

Antitoxin

Cro/C1-type helix-turn-helix domain

(4-57)


Sequences

Toxin        


Download         Length: 290 a.a.        Molecular weight: 32912.50 Da        Isoelectric Point: 4.7903

>T244697 WP_002378351.1 NZ_CP097069:c1360902-1360033 [Enterococcus faecalis]
MVGNVIQIVTEKLSSLPFIEGIVLGGSRARGTHTENSDIDIGIYYNSDSFDLTAINQIATELDDKNRNNLVVPPGAWGDW
INGGGWLFINGYHVDLILRDIKRVEQIIKDTEQGIVTANYQTGHPHGYISAMYRGELAISKILYAKNESLCELKKQAEIY
PTALKKSLMNFFIFEAEFSLMFVKANAGVEDKYYIAGHVFRIISCLNQVLFACNNAYCINEKKAIKLLETFEYKPEKYAE
RVNHIFEVLGLSLFECYDMTEKLYNEVNEIVSEINNFLNEESSDERKQI

Download         Length: 870 bp

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8365.68 Da        Isoelectric Point: 4.5510

>AT244697 WP_000205227.1 NZ_CP097069:c1361141-1360917 [Enterococcus faecalis]
MTTAEMIKELCEQMNISVSELARRIGQTPQNFNKKLQRETVTLDELKAIADVLGVKFVQAFILPDGEEIKISNE

Download         Length: 225 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A193AUR0

Antitoxin

Source ID Structure

References