Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | Xre-MNT/HTH_26(antitoxin) |
| Location | 1360033..1361141 | Replicon | chromosome |
| Accession | NZ_CP097069 | ||
| Organism | Enterococcus faecalis strain AT40a | ||
Toxin (Protein)
| Gene name | MNTss | Uniprot ID | A0A193AUR0 |
| Locus tag | M2912_RS06550 | Protein ID | WP_002378351.1 |
| Coordinates | 1360033..1360902 (-) | Length | 290 a.a. |
Antitoxin (Protein)
| Gene name | Xress | Uniprot ID | - |
| Locus tag | M2912_RS06555 | Protein ID | WP_000205227.1 |
| Coordinates | 1360917..1361141 (-) | Length | 75 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| M2912_RS06530 (1356304) | 1356304..1357623 | - | 1320 | WP_002338419.1 | IS1380-like element ISSsu5 family transposase | - |
| M2912_RS06535 (1357851) | 1357851..1358252 | - | 402 | WP_002401582.1 | phosphoribosyltransferase family protein | - |
| M2912_RS06540 (1358422) | 1358422..1359285 | - | 864 | WP_002294505.1 | aminoglycoside nucleotidyltransferase ANT(6)-Ia | - |
| M2912_RS06545 (1359318) | 1359318..1360052 | - | 735 | WP_000662263.1 | class I SAM-dependent methyltransferase | - |
| M2912_RS06550 (1360033) | 1360033..1360902 | - | 870 | WP_002378351.1 | nucleotidyltransferase domain-containing protein | Toxin |
| M2912_RS06555 (1360917) | 1360917..1361141 | - | 225 | WP_000205227.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| M2912_RS06560 (1361284) | 1361284..1361370 | - | 87 | Protein_1261 | site-specific recombinase | - |
| M2912_RS06565 (1361559) | 1361559..1362860 | + | 1302 | Protein_1262 | ISL3 family transposase | - |
| M2912_RS06570 (1363169) | 1363169..1363972 | - | 804 | WP_002294514.1 | lincosamide nucleotidyltransferase Lnu(B) | - |
| M2912_RS06575 (1364026) | 1364026..1365510 | - | 1485 | WP_002294513.1 | ABC-F type ribosomal protection protein Lsa(E) | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | erm(B) / ant(6)-Ia / lnu(B) / lsa(E) / aph(3')-III / aac(6')-aph(2'') | - | 1189036..1410933 | 221897 | |
| - | inside | IScluster/Tn | erm(B) / ant(6)-Ia / lnu(B) / lsa(E) / aph(3')-III / aac(6')-aph(2'') | - | 1348642..1379331 | 30689 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 290 a.a. Molecular weight: 32912.50 Da Isoelectric Point: 4.7903
>T244697 WP_002378351.1 NZ_CP097069:c1360902-1360033 [Enterococcus faecalis]
MVGNVIQIVTEKLSSLPFIEGIVLGGSRARGTHTENSDIDIGIYYNSDSFDLTAINQIATELDDKNRNNLVVPPGAWGDW
INGGGWLFINGYHVDLILRDIKRVEQIIKDTEQGIVTANYQTGHPHGYISAMYRGELAISKILYAKNESLCELKKQAEIY
PTALKKSLMNFFIFEAEFSLMFVKANAGVEDKYYIAGHVFRIISCLNQVLFACNNAYCINEKKAIKLLETFEYKPEKYAE
RVNHIFEVLGLSLFECYDMTEKLYNEVNEIVSEINNFLNEESSDERKQI
MVGNVIQIVTEKLSSLPFIEGIVLGGSRARGTHTENSDIDIGIYYNSDSFDLTAINQIATELDDKNRNNLVVPPGAWGDW
INGGGWLFINGYHVDLILRDIKRVEQIIKDTEQGIVTANYQTGHPHGYISAMYRGELAISKILYAKNESLCELKKQAEIY
PTALKKSLMNFFIFEAEFSLMFVKANAGVEDKYYIAGHVFRIISCLNQVLFACNNAYCINEKKAIKLLETFEYKPEKYAE
RVNHIFEVLGLSLFECYDMTEKLYNEVNEIVSEINNFLNEESSDERKQI
Download Length: 870 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|