Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 1350461..1351598 Replicon chromosome
Accession NZ_CP097069
Organism Enterococcus faecalis strain AT40a

Toxin (Protein)


Gene name zeta Uniprot ID -
Locus tag M2912_RS06485 Protein ID WP_002401483.1
Coordinates 1350461..1351324 (-) Length 288 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID R2XCR7
Locus tag M2912_RS06490 Protein ID WP_000301765.1
Coordinates 1351326..1351598 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2912_RS06455 (1346259) 1346259..1347026 - 768 WP_002357481.1 ribonuclease HII -
M2912_RS06460 (1347028) 1347028..1347879 - 852 WP_002357480.1 ribosome biogenesis GTPase YlqF -
M2912_RS06465 (1348155) 1348155..1348586 - 432 Protein_1242 ketopantoate reductase C-terminal domain-containing protein -
M2912_RS06470 (1348642) 1348642..1349322 - 681 WP_010710189.1 IS6-like element IS1216 family transposase -
M2912_RS06475 (1349396) 1349396..1349683 - 288 Protein_1244 DnaJ domain-containing protein -
M2912_RS06480 (1349703) 1349703..1350020 - 318 WP_002333463.1 hypothetical protein -
M2912_RS06485 (1350461) 1350461..1351324 - 864 WP_002401483.1 zeta toxin family protein Toxin
M2912_RS06490 (1351326) 1351326..1351598 - 273 WP_000301765.1 antitoxin Antitoxin
M2912_RS06495 (1351615) 1351615..1351830 - 216 WP_002295735.1 peptide-binding protein -
M2912_RS06500 (1351929) 1351929..1352825 - 897 WP_002387620.1 ParA family protein -
M2912_RS06505 (1352928) 1352928..1353188 - 261 Protein_1250 topoisomerase DNA-binding C4 zinc finger domain-containing protein -
M2912_RS06510 (1353358) 1353358..1354095 - 738 WP_002292226.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B) -
M2912_RS06515 (1354220) 1354220..1354315 - 96 WP_001809736.1 23S rRNA methyltransferase attenuation leader peptide -
M2912_RS06520 (1354384) 1354384..1354506 - 123 Protein_1253 peptide-binding protein -
M2912_RS06525 (1354626) 1354626..1356152 - 1527 WP_025191980.1 type IA DNA topoisomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element erm(B) / ant(6)-Ia / lnu(B) / lsa(E) / aph(3')-III / aac(6')-aph(2'') - 1189036..1410933 221897
- inside IScluster/Tn erm(B) / ant(6)-Ia / lnu(B) / lsa(E) / aph(3')-III / aac(6')-aph(2'') - 1348642..1379331 30689


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-213)

Antitoxin

Bacterial epsilon antitoxin

(2-90)


Sequences

Toxin        


Download         Length: 288 a.a.        Molecular weight: 32486.06 Da        Isoelectric Point: 6.9965

>T244696 WP_002401483.1 NZ_CP097069:c1351324-1350461 [Enterococcus faecalis]
MANIVNFTDKQFENRLNDNLEELIQGKKAVESPTAFLLGGQPGSGKTSLRSAILEETQGNVIVIDNDTFKQQHPNFDELA
KLYEKDVVKHVTPYSNRMTEAIISRLSDQGYNLVIEGTGRTTDVPIQTATMLQAKGYETKMYVMAVPKINSYLGTIERYE
TMYADDPMTARATPKQAHDIVVKNLPTNLETLHKTGLFSDIRLYNREGVKLYSRLETPSISPKETLERELNRKVSGKEIQ
PTLERIEQKMLQNQHQETPEFKAIQQKMESLQPPTPPIPKTPKLPGL

Download         Length: 864 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10721.25 Da        Isoelectric Point: 6.4676

>AT244696 WP_000301765.1 NZ_CP097069:c1351598-1351326 [Enterococcus faecalis]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKNDSQLLEVNLLNQLKLAKRVNLFDYSLEELQAVHEYWRSMNRYS
KQVLNKEKVA

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 3Q8X
PDB 1GVN
AlphaFold DB A0A829F0A3

References