Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 2656436..2657007 Replicon chromosome
Accession NZ_CP097066
Organism Enterococcus faecalis strain AT49a

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag M2922_RS12625 Protein ID WP_174114068.1
Coordinates 2656436..2656777 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID R3JGB1
Locus tag M2922_RS12630 Protein ID WP_002354773.1
Coordinates 2656777..2657007 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2922_RS12620 (2652451) 2652451..2656065 - 3615 WP_002389470.1 DNA-directed RNA polymerase subunit beta -
M2922_RS12625 (2656436) 2656436..2656777 - 342 WP_174114068.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
M2922_RS12630 (2656777) 2656777..2657007 - 231 WP_002354773.1 hypothetical protein Antitoxin
M2922_RS12635 (2657422) 2657422..2657637 - 216 WP_002354768.1 zinc ribbon domain-containing protein -
M2922_RS12640 (2657776) 2657776..2658768 + 993 WP_002378862.1 biotin--[acetyl-CoA-carboxylase] ligase -
M2922_RS12645 (2658935) 2658935..2659573 - 639 WP_002378863.1 lytic polysaccharide monooxygenase -
M2922_RS12650 (2660259) 2660259..2661875 + 1617 WP_174114069.1 phosphatase PAP2/LCP family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13177.42 Da        Isoelectric Point: 8.8678

>T244682 WP_174114068.1 NZ_CP097066:c2656777-2656436 [Enterococcus faecalis]
MNVEKKYIPKKGDIVWIDFDPAAGKEIQKRRPGLVVSRYEFNRKTMFAVICPIISTIKNIPTRYTLPDDIETHGQVVISQ
LQSLDFTERKLSQIEHLPLKDMAKIDQIIEYIF

Download         Length: 342 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8677.67 Da        Isoelectric Point: 4.3313

>AT244682 WP_002354773.1 NZ_CP097066:c2657007-2656777 [Enterococcus faecalis]
MLTTKSRRQGSSVVLTLPTDNGKKPKVDQEYIVMYSDDGTITLVPKIQDPFSEGPEGEYYEKDEWHDLAPEGRELF

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2A812

References