Detailed information of TA system TA024467

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB-HicA
• Location: 1485147..1485592
• Replicon: chromosome
• Accession: NC_013642
• Organism: Thermotoga naphthophila RKU-10

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: D2C4B8
• Locus tag: TNAP_RS07675
• Protein ID: WP_008195297.1
• Coordinates: 1485362..1485592 (+)
• Length: 77 a.a.

Antitoxin (Protein)

• Gene name: hicA
• Uniprot ID: Q9X145
• Locus tag: TNAP_RS07670
• Protein ID: WP_004083352.1
• Coordinates: 1485147..1485365 (+)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
TNAP_RS07660	1481418..1482809	-	1392	WP_004083362.1	radical SAM protein	-
TNAP_RS09530	1482911..1483006	-	96	WP_010865309.1	Cys-rich RiPP peptide	-
TNAP_RS09535	1483083..1483247	-	165	WP_012896512.1	hypothetical protein	-
TNAP_RS07665	1483443..1485050	+	1608	WP_011943917.1	helix-turn-helix domain-containing protein	-
TNAP_RS07670	1485147..1485365	+	219	WP_004083352.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
TNAP_RS07675	1485362..1485592	+	231	WP_008195297.1	type II toxin-antitoxin system HicA family toxin	Toxin
TNAP_RS07680	1485615..1485827	+	213	WP_004079908.1	hypothetical protein	-
TNAP_RS09380	1485817..1485966	+	150	WP_081434644.1	type II toxin-antitoxin system HicA family toxin	-
TNAP_RS09385	1486037..1486438	-	402	Protein_1494	ABC transporter ATP-binding protein	-
TNAP_RS07690	1486502..1487272	-	771	WP_011943918.1	ABC transporter permease	-
TNAP_RS07695	1487276..1487710	-	435	WP_004079914.1	ABC transporter permease	-
TNAP_RS07700	1487928..1488734	-	807	WP_004079915.1	ABC transporter permease	-
TNAP_RS07705	1488728..1489489	-	762	WP_004079916.1	ABC transporter permease	-
TNAP_RS07710	1489440..1490216	-	777	WP_004079917.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1465687..1492392	26705

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (10-64)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (6-57)

Sequences

Toxin

Protein

• Length: 77 a.a.
• Molecular weight: 8881.54 Da
• Isoelectric Point: 11.0394

>T24467 WP_008195297.1 NC_013642:1485362-1485592 [Thermotoga naphthophila RKU-10]
MSYLPIVDPKTMEKVLLKLGFQRVRQKGSHVFYRHSNGRYTTIPFHARALPKSLIRKIIREAGISVEEFKKVLENL

Nucleotide

• Length: 231 bp

>T24467 NC_013642:1485362-1485592 [Thermotoga naphthophila RKU-10]
TTGAGTTATCTTCCAATAGTTGATCCAAAAACTATGGAAAAGGTTTTACTGAAACTTGGATTTCAACGTGTTCGCCAAAA
AGGAAGTCATGTGTTCTACAGGCACAGCAATGGCAGATATACGACCATCCCATTTCATGCAAGAGCCTTGCCCAAATCAC
TTATAAGAAAAATCATCCGTGAAGCGGGTATATCAGTGGAGGAATTCAAGAAAGTACTTGAGAATCTGTGA

Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 8183.29 Da
• Isoelectric Point: 4.0887

>AT24467 WP_004083352.1 NC_013642:1485147-1485365 [Thermotoga naphthophila RKU-10]
VRKIFTAIIEYDPETKQYVGMVPDVPGVHTVGSSLEEVRRNLKEVLELVLEEAGDEINHQEFVALEMIEVET

Nucleotide

• Length: 219 bp

>AT24467 NC_013642:1485147-1485365 [Thermotoga naphthophila RKU-10]
GTGCGCAAAATTTTCACAGCTATCATTGAATACGATCCTGAAACAAAGCAATATGTTGGAATGGTTCCGGACGTTCCGGG
TGTGCATACTGTAGGTAGTTCCTTAGAAGAAGTGAGAAGGAATTTAAAAGAGGTGCTTGAACTCGTATTGGAGGAAGCAG
GAGATGAAATAAATCACCAGGAATTCGTGGCTCTTGAGATGATAGAGGTGGAAACTTGA

Structures

Toxin

• AlphaFold DB: A0A0B5L026

Antitoxin

• AlphaFold DB: A0A0A6N0B1