Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 1485147..1485592 Replicon chromosome
Accession NC_013642
Organism Thermotoga naphthophila RKU-10

Toxin (Protein)


Gene name hicA Uniprot ID D2C4B8
Locus tag TNAP_RS07675 Protein ID WP_008195297.1
Coordinates 1485362..1485592 (+) Length 77 a.a.

Antitoxin (Protein)


Gene name hicA Uniprot ID Q9X145
Locus tag TNAP_RS07670 Protein ID WP_004083352.1
Coordinates 1485147..1485365 (+) Length 73 a.a.

Genomic Context

TNAP_RS07665TNAP_RS07670TNAP_RS07675TNAP_RS07680TNAP_RS09380TNAP_RS07660TNAP_RS09530TNAP_RS09535TNAP_RS09385TNAP_RS07690TNAP_RS07695TNAP_RS07700TNAP_RS07705TNAP_RS07710
Location: 1483443..1485050 (1608 bp)
Type: Others
Protein ID: WP_011943917.1
Location: 1485147..1485365 (219 bp)
Type: Antitoxin
Protein ID: WP_004083352.1
Location: 1485362..1485592 (231 bp)
Type: Toxin
Protein ID: WP_008195297.1
Location: 1485615..1485827 (213 bp)
Type: Others
Protein ID: WP_004079908.1
Location: 1485817..1485966 (150 bp)
Type: Others
Protein ID: WP_081434644.1
Location: 1481418..1482809 (1392 bp)
Type: Others
Protein ID: WP_004083362.1
Location: 1482911..1483006 (96 bp)
Type: Others
Protein ID: WP_010865309.1
Location: 1483083..1483247 (165 bp)
Type: Others
Protein ID: WP_012896512.1
Location: 1486037..1486438 (402 bp)
Type: Others
Protein ID: Protein_1494
Location: 1486502..1487272 (771 bp)
Type: Others
Protein ID: WP_011943918.1
Location: 1487276..1487710 (435 bp)
Type: Others
Protein ID: WP_004079914.1
Location: 1487928..1488734 (807 bp)
Type: Others
Protein ID: WP_004079915.1
Location: 1488728..1489489 (762 bp)
Type: Others
Protein ID: WP_004079916.1
Location: 1489440..1490216 (777 bp)
Type: Others
Protein ID: WP_004079917.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
TNAP_RS076601481418..1482809-1392WP_004083362.1radical SAM protein-
TNAP_RS095301482911..1483006-96WP_010865309.1Cys-rich RiPP peptide-
TNAP_RS095351483083..1483247-165WP_012896512.1hypothetical protein-
TNAP_RS076651483443..1485050+1608WP_011943917.1helix-turn-helix domain-containing protein-
TNAP_RS076701485147..1485365+219WP_004083352.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
TNAP_RS076751485362..1485592+231WP_008195297.1type II toxin-antitoxin system HicA family toxinToxin
TNAP_RS076801485615..1485827+213WP_004079908.1hypothetical protein-
TNAP_RS093801485817..1485966+150WP_081434644.1type II toxin-antitoxin system HicA family toxin-
TNAP_RS093851486037..1486438-402Protein_1494ABC transporter ATP-binding protein-
TNAP_RS076901486502..1487272-771WP_011943918.1ABC transporter permease-
TNAP_RS076951487276..1487710-435WP_004079914.1ABC transporter permease-
TNAP_RS077001487928..1488734-807WP_004079915.1ABC transporter permease-
TNAP_RS077051488728..1489489-762WP_004079916.1ABC transporter permease-
TNAP_RS077101489440..1490216-777WP_004079917.1ABC transporter ATP-binding protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--1465687..149239226705


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(10-64)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(6-57)


Sequences

Toxin        


Download         Length: 77 a.a.        Molecular weight: 8881.54 Da        Isoelectric Point: 11.0394

>T24467 WP_008195297.1 NC_013642:1485362-1485592 [Thermotoga naphthophila RKU-10]
MSYLPIVDPKTMEKVLLKLGFQRVRQKGSHVFYRHSNGRYTTIPFHARALPKSLIRKIIREAGISVEEFKKVLENL

Download         Length: 231 bp

>T24467 NC_013642:1485362-1485592 [Thermotoga naphthophila RKU-10]
TTGAGTTATCTTCCAATAGTTGATCCAAAAACTATGGAAAAGGTTTTACTGAAACTTGGATTTCAACGTGTTCGCCAAAA
AGGAAGTCATGTGTTCTACAGGCACAGCAATGGCAGATATACGACCATCCCATTTCATGCAAGAGCCTTGCCCAAATCAC
TTATAAGAAAAATCATCCGTGAAGCGGGTATATCAGTGGAGGAATTCAAGAAAGTACTTGAGAATCTGTGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8183.29 Da        Isoelectric Point: 4.0887

>AT24467 WP_004083352.1 NC_013642:1485147-1485365 [Thermotoga naphthophila RKU-10]
VRKIFTAIIEYDPETKQYVGMVPDVPGVHTVGSSLEEVRRNLKEVLELVLEEAGDEINHQEFVALEMIEVET

Download         Length: 219 bp

>AT24467 NC_013642:1485147-1485365 [Thermotoga naphthophila RKU-10]
GTGCGCAAAATTTTCACAGCTATCATTGAATACGATCCTGAAACAAAGCAATATGTTGGAATGGTTCCGGACGTTCCGGG
TGTGCATACTGTAGGTAGTTCCTTAGAAGAAGTGAGAAGGAATTTAAAAGAGGTGCTTGAACTCGTATTGGAGGAAGCAG
GAGATGAAATAAATCACCAGGAATTCGTGGCTCTTGAGATGATAGAGGTGGAAACTTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0B5L026

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0A6N0B1

References