244664

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 23764..24901 Replicon plasmid pAT02-c
Accession NZ_CP097064
Organism Enterococcus faecium strain AT02

Toxin (Protein)


Gene name zeta Uniprot ID -
Locus tag M2900_RS13395 Protein ID WP_231428275.1
Coordinates 24038..24901 (+) Length 288 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID F0EPW7
Locus tag M2900_RS13390 Protein ID WP_005237730.1
Coordinates 23764..24036 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2900_RS13370 (M2900_13365) 19679..20296 + 618 WP_126263923.1 recombinase family protein -
M2900_RS13375 (M2900_13370) 20296..22440 + 2145 WP_231428277.1 type IA DNA topoisomerase -
M2900_RS13380 (M2900_13375) 22543..23439 + 897 WP_231428276.1 ParA family protein -
M2900_RS13385 (M2900_13380) 23531..23746 + 216 WP_001835296.1 peptide-binding protein -
M2900_RS13390 (M2900_13385) 23764..24036 + 273 WP_005237730.1 antitoxin Antitoxin
M2900_RS13395 (M2900_13390) 24038..24901 + 864 WP_231428275.1 zeta toxin family protein Toxin
M2900_RS13400 (M2900_13395) 25164..25901 - 738 WP_001038790.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B) -
M2900_RS13405 (M2900_13400) 26026..26109 - 84 WP_031929417.1 23S rRNA methyltransferase attenuator leader peptide ErmL -
M2900_RS13515 26158..26241 - 84 Protein_30 MLS leader peptide -
M2900_RS13410 (M2900_13405) 26897..27094 + 198 WP_231415653.1 hypothetical protein -
M2900_RS13415 (M2900_13410) 27124..27804 - 681 WP_127821369.1 IS6 family transposase -
M2900_RS13420 (M2900_13415) 27878..28468 + 591 Protein_33 GMP synthase (glutamine-hydrolyzing) -
M2900_RS13425 (M2900_13420) 28552..29625 - 1074 WP_105459893.1 23S rRNA (adenine(2503)-C(8))-methyltransferase Cfr(D) -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid erm(B) / Cfr(D) - 1..33236 33236


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-214)

Antitoxin

Bacterial epsilon antitoxin

(2-90)


Sequences

Toxin        


Download         Length: 288 a.a.        Molecular weight: 32418.01 Da        Isoelectric Point: 6.9964

>T244664 WP_231428275.1 NZ_CP097064:24038-24901 [Enterococcus faecium]
MANIVNFTDKQFENRLNDNLEELVQGKKAVESPTAFLLGGQPGSGKTSLRSAIFEETQGNVIVIDNDTFKQQHPNFDELV
KLYEKDVVKHVTPYSNRMTEAIISRLSDQGYNLVIEGTGRTTDVPIQTATMLQAKGYETKMYVMAVPKINSYLGTIERYE
TMYADDPMTARATPKQAHDIVVKNLPTNLETLHKTGLFSDIRLYNREGVKLYSSLETPSISPKETLERELNRKVSGKEIQ
PTLERIEQKMVLNKHQETPEFKAIQQKLESLQPPTPPIPKTPKLPGI

Download         Length: 864 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10735.27 Da        Isoelectric Point: 6.4687

>AT244664 WP_005237730.1 NZ_CP097064:23764-24036 [Enterococcus faecium]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKNDSQLLEVNLLNQLKLAKRVNLFEYSLEELQAVHEYWRSMNRYS
KQVLNKEKVA

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A475M8I8

References