Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 454691..455262 Replicon chromosome
Accession NZ_CP097061
Organism Enterococcus faecium strain AT02

Toxin (Protein)


Gene name mazF Uniprot ID Q3Y2B8
Locus tag M2900_RS02195 Protein ID WP_002286801.1
Coordinates 454921..455262 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A828ZZN9
Locus tag M2900_RS02190 Protein ID WP_002323011.1
Coordinates 454691..454921 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2900_RS02165 (M2900_02165) 450172..451500 + 1329 WP_002327434.1 FAD-containing oxidoreductase -
M2900_RS02170 (M2900_02170) 451522..452148 + 627 WP_002286816.1 cysteine hydrolase -
M2900_RS02175 (M2900_02175) 452331..452912 + 582 WP_002327433.1 TetR/AcrR family transcriptional regulator -
M2900_RS02180 (M2900_02180) 453277..453852 + 576 WP_002352505.1 SOS response-associated peptidase family protein -
M2900_RS02185 (M2900_02185) 454057..454395 - 339 WP_002306002.1 hypothetical protein -
M2900_RS02190 (M2900_02190) 454691..454921 + 231 WP_002323011.1 hypothetical protein Antitoxin
M2900_RS02195 (M2900_02195) 454921..455262 + 342 WP_002286801.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
M2900_RS02200 (M2900_02200) 456112..456297 + 186 WP_002304207.1 hypothetical protein -
M2900_RS02205 (M2900_02205) 456567..457729 + 1163 WP_142431476.1 IS3 family transposase -
M2900_RS02210 (M2900_02210) 457860..458102 + 243 Protein_438 LPXTG cell wall anchor domain-containing protein -
M2900_RS02215 (M2900_02215) 458175..459071 + 897 Protein_439 class C sortase -
M2900_RS02220 (M2900_02220) 459252..459926 + 675 WP_038811248.1 response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13302.68 Da        Isoelectric Point: 9.9044

>T244663 WP_002286801.1 NZ_CP097061:454921-455262 [Enterococcus faecium]
VSEERIYIPKKGDIVWIDFDPSVGKEIQKRRPGLVVSRYEFNRKTMFSVICPITSTIKNLPTRYSLPEELDIKGQVIITQ
LKSLDFKERKLKKIENLPLQDMAKIDQIIQYMF

Download         Length: 342 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8523.39 Da        Isoelectric Point: 3.9078

>AT244663 WP_002323011.1 NZ_CP097061:454691-454921 [Enterococcus faecium]
MLVTKSRLQGSSVVVTLPSDNGKKPSENQEYIVVYSDDGTITLVPKIEDPFSGGEEAEYYEKDEWEDLTPEGREIL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FD66

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZZN9

References