Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 184285..184814 Replicon chromosome
Accession NZ_CP097061
Organism Enterococcus faecium strain AT02

Toxin (Protein)


Gene name relE Uniprot ID A0A2D0BMD7
Locus tag M2900_RS00915 Protein ID WP_002319468.1
Coordinates 184548..184814 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID C9B8W8
Locus tag M2900_RS00910 Protein ID WP_002294199.1
Coordinates 184285..184548 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2900_RS00900 (M2900_00900) 181660..183483 + 1824 WP_002294202.1 APC family permease -
M2900_RS00905 (M2900_00905) 183625..183810 - 186 WP_038811433.1 hypothetical protein -
M2900_RS00910 (M2900_00910) 184285..184548 + 264 WP_002294199.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
M2900_RS00915 (M2900_00915) 184548..184814 + 267 WP_002319468.1 Txe/YoeB family addiction module toxin Toxin
M2900_RS00920 (M2900_00920) 185015..185504 + 490 Protein_182 mannosyl-glycoprotein endo-beta-N-acetylglucosamidase -
M2900_RS00925 (M2900_00925) 186046..186717 - 672 WP_002319469.1 ABC transporter permease -
M2900_RS00930 (M2900_00930) 186714..187631 - 918 WP_002319470.1 osmoprotectant ABC transporter substrate-binding protein -
M2900_RS00935 (M2900_00935) 187628..188269 - 642 WP_002293405.1 ABC transporter permease -
M2900_RS00940 (M2900_00940) 188273..189448 - 1176 WP_002294192.1 betaine/proline/choline family ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(22-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10632.08 Da        Isoelectric Point: 9.9931

>T244662 WP_002319468.1 NZ_CP097061:184548-184814 [Enterococcus faecium]
MSNYTVAIKNSAKVDLRKIKQTNLKKQFEEVIQTLKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRVVYKVDEENKVAEI
YSAWTHYE

Download         Length: 267 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10016.03 Da        Isoelectric Point: 4.1207

>AT244662 WP_002294199.1 NZ_CP097061:184285-184548 [Enterococcus faecium]
MANTTMNPSTARKNFYQLLKEVNENHTEIEIISDRSGNNAVLIGLEDWRAIQETLFLEQTGTLDKVRDREKDDSGFTNID
DIDWEAL

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2D0BMD7

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZU84

References